Current Status of Stromal Vascular Fraction from Adipose Tissue in the Clinical Application for Osteoarthritis Treatment.

IF 4.4 4区医学 Q2 CELL & TISSUE ENGINEERING

Tissue engineering and regenerative medicine Pub Date : 2025-06-06 DOI:10.1007/s13770-025-00722-z

Gun-Il Im

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引用次数: 0

Abstract

Background: Recently, regenerative medicine based on cell-based therapies has emerged as a therapeutic possibility for the management of osteoarthritis (OA). Stromal vascular fraction (SVF) is a cellular mixture obtained from lipoaspirate processed through either mechanical or enzymatic separation. SVF has been applied in several countries to treat OA patients without robust supporting evidence or comprehensive evaluation.

Methods: This review purposes to summarize clinical evidence regarding SVF as a therapeutic for OA and to introduce the author's perspective. Eleven studies were found suitable for this review; out of these, seven were randomized clinical trials and four were cohort studies.

Results: A review of controlled studies suggests that SVF may offer better symptomatic relief than placebo or hyaluronic acid in the long term, and the effect of SVF is comparable to that of bone marrow aspirate concentrates.

Conclusion: Prospective studies with improved control over the cell isolation method, dosage, and patient selection are necessary to provide convincing evidence of the benefits of SVF in treating OA.

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脂肪组织间质血管组分在骨关节炎治疗中的临床应用现状。

背景：最近，基于细胞疗法的再生医学已经成为治疗骨关节炎（OA）的一种可能。基质血管组分（SVF）是通过机械或酶分离从抽脂液中获得的细胞混合物。SVF已在一些国家用于治疗OA患者，但没有强有力的支持证据或全面的评估。方法：本综述旨在总结SVF治疗OA的临床证据，并介绍作者的观点。11项研究被发现适合本综述；其中，7项是随机临床试验，4项是队列研究。结果：一项对照研究综述表明，SVF可能比安慰剂或透明质酸提供更好的长期症状缓解，并且SVF的效果与骨髓抽液浓缩液相当。结论：有必要对细胞分离方法、剂量和患者选择的控制进行前瞻性研究，以提供令人信服的证据，证明SVF治疗OA的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue engineering and regenerative medicine CELL & TISSUE ENGINEERING-ENGINEERING, BIOMEDICAL

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Tissue Engineering and Regenerative Medicine (Tissue Eng Regen Med, TERM), the official journal of the Korean Tissue Engineering and Regenerative Medicine Society, is a publication dedicated to providing research- based solutions to issues related to human diseases. This journal publishes articles that report substantial information and original findings on tissue engineering, medical biomaterials, cells therapy, stem cell biology and regenerative medicine.