The associations between plasma fluoride and bone mass in children and adolescents.

IF 3.1 3区医学 Q1 PEDIATRICS

Pediatric Research Pub Date : 2025-06-05 DOI:10.1038/s41390-025-04069-y

Jung Yoon Park, Yongyeon Choi, Sangshin Park

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引用次数: 0

Abstract

Background: Peak bone mass is attained during childhood and adolescence and is a key determinant of osteoporosis risk later in life. This study investigated the associations between plasma fluoride levels and bone mineral density (BMD) and bone mineral content (BMC) in children and adolescents.

Methods: We analyzed data from 2851 children and adolescents (8-18 years), collected through the National Health and Nutrition Examination Survey 2013-2016. We performed multivariable linear regression analyses to examine the relationships between plasma fluoride levels and bone mass, adjusting for sociodemographic factors, calcium and vitamin D intake, and physical activity.

Results: Plasma fluoride levels among children and adolescents aged 8-18 were not significantly associated with BMD or BMC, except in girls aged 12-18. In this group, higher fluoride levels were associated with higher BMD in the total body (B = 0.025, P = 0.031) and legs (B = 0.031, P = 0.037). However, no association was found between plasma fluoride levels and BMC in girls aged 12-18.

Conclusion: Higher fluoride levels were statistically significantly associated with higher BMD in girls aged 12-18. However, in other age groups and sexes, fluoride levels were not significantly associated with BMD or BMC levels.

Impact: Except for girls aged 12-18, plasma fluoride levels among children and adolescents aged 8-18 were not statistically significantly associated with bone mineral density (BMD) or bone mineral content (BMC). Higher fluoride levels in girls aged 12-18 were associated with higher BMD in the total body and legs. Our findings indicated that higher fluoride exposure may not be associated with lower BMD or BMC. Further investigation is warranted to clarify the effects of fluoride exposure on bone health and the underlying mechanisms in young populations.

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儿童和青少年血浆氟化物与骨量的关系

背景：骨量高峰发生在儿童和青少年时期，是以后生活中骨质疏松风险的关键决定因素。本研究探讨了儿童和青少年血浆氟化物水平与骨密度（BMD）和骨矿物质含量（BMC）之间的关系。方法：对2013-2016年全国健康与营养检查调查收集的2851名8-18岁儿童和青少年的数据进行分析。我们进行了多变量线性回归分析，以检验血浆氟化物水平与骨量之间的关系，并对社会人口因素、钙和维生素D摄入量以及身体活动进行了调整。结果：除12-18岁的女孩外，8-18岁的儿童和青少年血浆氟化物水平与BMD或BMC无显著相关性。在这一组中，较高的氟化物水平与较高的全身骨密度（B = 0.025, P = 0.031）和腿部骨密度（B = 0.031, P = 0.037）相关。然而，在12-18岁的女孩中，血浆氟化物水平与BMC之间没有关联。结论：较高的氟化物水平与12-18岁女孩较高的骨密度有统计学意义。然而，在其他年龄组和性别中，氟化物水平与骨密度或BMC水平没有显著相关性。影响：除12-18岁的女孩外，8-18岁的儿童和青少年血浆氟化物水平与骨密度（BMD）或骨矿物质含量（BMC）没有统计学上的显著相关性。在12-18岁的女孩中，较高的氟化物水平与较高的全身和腿部骨密度有关。我们的研究结果表明，较高的氟化物暴露可能与较低的骨密度或BMC无关。有必要进行进一步调查，以阐明氟化物暴露对年轻人群骨骼健康的影响及其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Research 医学-小儿科

CiteScore

6.80

自引率

5.60%

发文量

473

审稿时长

3-8 weeks

期刊介绍： Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of children''s diseases and disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in vitro techniques relevant to developmental biology and medicine are acceptable, as are translational human studies