Post-infectious glomerulonephritis among children before and during the COVID-19 pandemic.

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-11-01 Epub Date: 2025-06-06 DOI:10.1007/s00467-025-06837-8

Eman Nooreddeen, Faten Almuteri, Mona Hamza Syrafi, Ahmed Alarabi, Khamisa Almokali, Mesbah Alshumrani, Sultan A Alharbi, Suzan Ali Alhazmi, Mossab Elkheir Imery Omer, Abdullah Zeid Alsuheili, Aeshah Alyahiwi, Sawsan Albatati, Saeed Alzabali, Osama Safdar, Khalid Alhasan, Jameela A Kari, Enas M Ghulam, Amer Alshengeti, Ibrahim Sandokji

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引用次数: 0

Abstract

Background: Post-infectious glomerulonephritis (PIGN) is a common cause of glomerulonephritis in children worldwide. The coronavirus disease 2019 (COVID-19) pandemic impacted the epidemiology of several infectious diseases; however, little is known about its effect on the epidemiology of PIGN. This study compared the epidemiology, clinical presentations, and outcomes of childhood PIGN before and during the COVID-19 pandemic.

Methods: This multicenter case control study involved six Saudi Arabian centers. Children aged 0-18 years diagnosed with PIGN from 2016 to 2023 were included. The clinical, laboratory, and outcome data of children diagnosed before and during the COVID-19 pandemic (2016-2019 and 2020-2023) were compared.

Results: A total of 141 patients were enrolled. Patients who presented during the pandemic were younger, and the clinical presentation of PIGN was milder, particularly regarding the rate of oliguria, and the severity of proteinuria in patients with acute post-streptococcal glomerulonephritis. A lower median C3 level was found in the pre-COVID-19 pandemic cohort. More patients with high anti-streptolysin O antibody levels were noted before the pandemic, while more cases had positive GAS throat cultures during the pandemic.

Conclusions: PIGN incidence decreased during the early COVID-19 pandemic (2020-2022), followed by a resurgence of cases with an altered seasonality pattern. During the pandemic, children with PIGN were younger and had milder disease severity.

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COVID-19大流行之前和期间儿童的感染后肾小球肾炎

背景：感染后肾小球肾炎（PIGN）是世界范围内儿童肾小球肾炎的常见病因。2019冠状病毒病（COVID-19）大流行对几种传染病流行病学的影响；然而，它对PIGN流行病学的影响知之甚少。本研究比较了COVID-19大流行之前和期间儿童PIGN的流行病学、临床表现和结果。方法：本多中心病例对照研究涉及6个沙特阿拉伯中心。纳入了2016年至2023年诊断为PIGN的0-18岁儿童。比较了COVID-19大流行之前和期间（2016-2019年和2020-2023年）诊断的儿童的临床、实验室和结局数据。结果：共纳入141例患者。在大流行期间出现的患者更年轻，PIGN的临床表现较轻，特别是在急性链球菌感染后肾小球肾炎患者的少尿率和蛋白尿严重程度方面。在covid -19大流行前队列中，C3水平中位数较低。在大流行之前，更多的患者具有高水平的抗溶血素O抗体，而在大流行期间，更多的病例具有阳性的GAS喉部培养。结论：在COVID-19大流行早期（2020-2022年），PIGN发病率下降，随后病例再次出现，但季节性模式发生改变。在大流行期间，患有PIGN的儿童年龄较小，疾病严重程度较轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.