The prognostic value of the triglyceride-glucose index in predicting recurrence of acute pancreatitis: a retrospective cohort study.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2025-06-05 DOI:10.1186/s12986-025-00956-7

Lihui Lin, Yansong Lin, Xin Ling, Zewen Zhang, Xianwen Guo, Zhen Ding

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引用次数: 0

Abstract

Background: Investigating the risk of acute pancreatitis (AP) recurrence is crucial because it affects public health and medical resources. The triglyceride-glucose index (TyG-i) is recognized as a reliable marker of insulin resistance (IR), which occurs after an AP attack. However, the predictive value of the TyG-i during the first AP for subsequent recurrence remains unclear.

Methods: Patients with their first AP episode between January 2014 and December 2023 were followed up retrospectively. Data on demographic characteristics, imaging findings, and laboratory examinations of their first episode and recurrences were collected. The TyG-i was calculated as follows: ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Factors associated with AP were evaluated using Cox regression analyses.

Results: A total of 853 patients were enrolled in our study, 180 (21.1%) of whom experienced a recurrence after the first AP episode. The recurrence rate was higher in the high TyG-i index group (n = 111, 26.0%) than in the low TyG-i index group (n = 69, 16.2%; P < 0.001). Cox regression analyses revealed TyG-i as an independent predictor of AP recurrence in all etiologies (hazard ratio [HR] = 1.535, P = 0.007), as well as for the recurrence of acute biliary pancreatitis (HR = 1.829, P = 0.035).

Conclusion: TyG-i status at the first AP episode could independently predict recurrence.

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甘油三酯-葡萄糖指数预测急性胰腺炎复发的预后价值：一项回顾性队列研究。

背景：调查急性胰腺炎（AP）复发的风险是至关重要的，因为它影响公共卫生和医疗资源。甘油三酯-葡萄糖指数（TyG-i）被认为是胰岛素抵抗（IR）的可靠标志，胰岛素抵抗发生在AP发作后。然而，TyG-i在首次AP期间对随后复发的预测价值尚不清楚。方法：对2014年1月至2023年12月首次AP发作的患者进行回顾性随访。收集其首次发作和复发的人口学特征、影像学表现和实验室检查数据。TyG-i计算公式为ln[空腹甘油三酯（mg/dL） ×空腹葡萄糖(mg/dL)/2]。使用Cox回归分析评估与AP相关的因素。结果：共有853例患者参加了我们的研究，其中180例（21.1%）在首次AP发作后复发。TyG-i指数高组复发率（n = 111, 26.0%）高于TyG-i指数低组(n = 69, 16.2%；结论：首次AP发作时TyG-i状态可独立预测AP复发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.