The current and emerging immunotherapy paradigm in small-cell lung cancer.

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2025-06-05 DOI:10.1038/s43018-025-00992-5

Kang Qin, Carl M Gay, Lauren A Byers, Jianjun Zhang

引用次数: 0

Abstract

Small-cell lung cancer (SCLC) is a highly aggressive malignancy with poor prognosis. For decades, etoposide-platinum-based chemotherapy had been the mainstay treatment for SCLC; however, despite initial high response rates, most patients developed resistance. In 2019, the US Food and Drug Administration approved the anti-PD-L1 antibody atezolizumab in combination with etoposide-platinum as the new first-line standard of care for extensive-stage SCLC, heralding a paradigm shift in SCLC therapy. This Review aims to provide an overview of the current landscape and emerging treatment strategies of immunotherapies in SCLC as well as highlight the importance of developing biomarkers to facilitate patient selection.

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当前和新兴的小细胞肺癌免疫治疗模式。

小细胞肺癌（SCLC）是一种高度侵袭性的恶性肿瘤，预后差。几十年来，依托泊肽-铂基化疗一直是SCLC的主要治疗方法；然而，尽管最初的反应率很高，但大多数患者产生了耐药性。2019年，美国食品和药物管理局批准抗pd - l1抗体atezolizumab联合依托泊赛-铂（etopoide -platinum）作为大分期SCLC的新的一线治疗标准，预示着SCLC治疗的范式转变。本综述旨在概述SCLC免疫疗法的现状和新兴治疗策略，并强调开发生物标志物以促进患者选择的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.