Peripheral Arterial Disease is Associated with Sensorimotor Peripheral Neuropathy in People with Type 2 Diabetes.

Q2 Medicine

Medical Journal of the Islamic Republic of Iran Pub Date : 2024-12-07 eCollection Date: 2024-01-01 DOI:10.47176/mjiri.38.143

Nahid Hashemi-Madani, Masoumeh Azadi, Alireza Khajavi, Zahra Emami, Mohammad E Khamseh

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Abstract

Background: Micro- and macro-vascular complications of diabetes seem to be interconnected. This study aimed to evaluate the association between peripheral arterial diseases (PAD) and diabetic sensorimotor peripheral neuropathy (DSPN).

Methods: This cross-sectional study was conducted among 748 people with type 2 diabetes (T2DM) referred to a tertiary care center between 2017 and 2022. PAD was defined as Ankle-brachial index (ABI) ≤ 0.9. Loss of protective sensation (LOPS) was applied for the detection of DSPN. Logistic regression analysis was used to determine the association between PAD and DSPN.

Results: The mean age of the participants was 59.6 (±8.8) years, and the median duration of diabetes was 10 (5-16) years. LOPS was detected in 491 individuals (65.6%). ABI ≤ 0.9 was associated with a significantly higher risk of LOPS (OR: 3.65, 95% Confidence Interval (CI): 1.97- 6.74). In addition, every 0.1 decrease in ABI increased the risk of LOPS by 21% (95%CI: 10- 34%). Toe brachial index (TBI) ≤0.7 was also associated with a significantly higher risk of LOPS (OR: 1.77, 95%CI: 1.28- 2.46). Each 0.1 decrease in TBI increased the risk of LOPS by 19% (95%CI: 10- 28%).

Conclusion: PAD is strongly associated with DSPN. Assessment of DSPN could be considered in the presence of PAD.

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2型糖尿病患者外周动脉疾病与感觉运动外周神经病变相关

背景：糖尿病的微血管和大血管并发症似乎是相互关联的。本研究旨在评估外周动脉疾病（PAD）与糖尿病感觉运动外周神经病变（DSPN）之间的关系。方法：本横断面研究在2017年至2022年期间在三级保健中心转诊的748例2型糖尿病（T2DM）患者中进行。PAD定义为踝肱指数（Ankle-brachial index， ABI）≤0.9。保护感觉丧失法（LOPS）检测DSPN。采用Logistic回归分析确定PAD与DSPN之间的关系。结果：参与者的平均年龄为59.6（±8.8）岁，糖尿病的中位病程为10（5-16）年。检出LOPS者491例（65.6%）。ABI≤0.9与LOPS风险显著增高相关（OR: 3.65, 95%可信区间（CI）： 1.97 ~ 6.74）。此外，ABI每降低0.1，LOPS的风险增加21% （95%CI: 10- 34%）。Toe - brachial index (TBI)≤0.7也与LOPS风险显著升高相关（OR: 1.77, 95%CI: 1.28- 2.46）。TBI每降低0.1，LOPS的风险增加19% （95%CI: 10- 28%）。结论：PAD与DSPN密切相关。如果存在PAD，可以考虑评估DSPN。

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