Experimental Study on New Polymer Dressings to Accelerate the Epithelialization in Wound Healing.

Abstract

Objectives: In this study, the authors applied polymers to an open wound and tried to determine their contribution to its closure or healing process.

Methods: Eighteen adult male Wistar albino rats weighing between 190 and 220 g were used in the experiment. The animals were randomly divided into groups (n=6): group 1, group 2, and group 3. First experimental group (polymer 1, IY-04-109 ) (n=6), second experimental group (polymer 2, IY-04-225) (n=6), third control group (meloline) (n=6). Wounds with a diameter of 0.3cm were created in the dorsal region of the animals; the polymer patches provided were fixed to the wound from both sides with 2 simple sutures.

Results: IY-04-109 and IY-04-225 are similar in composition and synthesis. They should both be biocompatible. Both are polydimethyl silicon-urea copolymers. The differences are that IY-04-109 used a PDMS with a molecular weight of 3200 g/mol, and urea was 13.9%. It was determined that polymer suturing upon the wound surface provided healing with healthy mucosa before scar tissue developed. Both groups, 1 and 2, were better than the control group. Polymer IY-04-225, used in group 2 animals, accelerated the epithelialization faster.

Conclusion: In IY-04-225, a PDMS with a molecular weight of 11,000 g/mol was used. The amount of urea is 9.6%. There is more PDMS in IY-04-225, and the molecular weight of the PDMS is very high. This can lead to differences in polymer surface properties, which may explain why the second group is slightly better.