Global trends and stratified analysis of aortic aneurysm mortality: insights from the GBD 2021 study.

IF 2.8 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Frontiers in Cardiovascular Medicine Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.3389/fcvm.2025.1496166
Weiguang Yang, Songzhe Wu, Feng Qi, Linlin Zhao, Bo Hai, Haoju Dong, Bufan Zhang, Ruirong Gao, Naishi Wu
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引用次数: 0

Abstract

Background: Aortic aneurysm (AA) is a serious cardiovascular disease with a high mortality rate. The aim of this study was to provide an up-to-date assessment of global AA mortality rates from 1990 to 2021, stratified by age, sex, and sociodemographic indices (SDI).

Method: This study utilized data from the Global Burden of Disease (GBD) 2021 analyzed the global burden of AA from 1990 to 2021. A stratified analysis by sex, age, and region was conducted based on the number of deaths and age-standardized death rates (ASDR). Furthermore, the ASDR trends were evaluated using age-period-cohort models and health inequality analysis methods. Existing data were also used to predict future AA mortality.

Result: In 2021, the global number of deaths due to AA increased to 153,927.20 (95% UI: 138,413.36-165,738.65), while ASDR decreased to 1.86 per 100,000 (95% UI: 1.67-2.00). The estimated annual percentage change in ASDR was -0.81 (95% CI: -0.95 to -0.66), and the average annual percentage change was -0.99 (95% CI: -1.07 to -0.90). Significant regional differences were observed, with high SDI regions experiencing a notable decrease in mortality rates, while low and low-middle SDI regions saw a substantial increase in deaths and an upward trend in mortality rates. The annual percentage change in mortality rates for those aged 55-59 years and older was positive, identifying this age group as a significant risk factor for increased AA-related mortality. At the national level, the three countries with the highest ASDR were Armenia, Montenegro, and Nauru, while the three countries with the lowest ASDR were Saudi Arabia, Tajikistan, and Afghanistan. Predictive analyses suggest that although the number of AA-related deaths is expected to continue rising, mortality rates are projected to decline.

Conclusion: While the global number of deaths from AA is anticipated to keep increasing, the ASDR is generally declining due to advances in medical care and improvements in early intervention. However, there are significant differences between countries and SDI regions. In low and low-middle SDI regions, the ASDR continues to rise, whereas in high and high-middle SDI regions, the ASDR is steadily decreasing but still remains higher than in lower SDI regions. Therefore, early screening and effective management of high-risk groups are crucial on a global scale.

主动脉瘤死亡率的全球趋势和分层分析:来自GBD 2021研究的见解
背景:主动脉瘤(Aortic动脉瘤,AA)是一种严重的心血管疾病,死亡率高。本研究的目的是提供1990年至2021年全球AA死亡率的最新评估,按年龄、性别和社会人口指数(SDI)分层。方法:本研究利用全球疾病负担(GBD) 2021的数据,分析1990 - 2021年AA的全球负担。根据死亡人数和年龄标准化死亡率(ASDR),按性别、年龄和地区进行分层分析。此外,使用年龄-时期-队列模型和健康不平等分析方法评估ASDR趋势。现有数据也用于预测未来的AA死亡率。结果:2021年,全球AA死亡人数增加到153,927.20人(95% UI: 138,413.36-165,738.65), ASDR下降到1.86 / 10万(95% UI: 1.67-2.00)。估计ASDR的年变化百分比为-0.81 (95% CI: -0.95至-0.66),平均年变化百分比为-0.99 (95% CI: -1.07至-0.90)。观察到显著的区域差异,高SDI区域的死亡率显著下降,而低SDI和中低SDI区域的死亡率大幅增加,死亡率呈上升趋势。55-59岁及以上人群死亡率的年百分比变化为正值,表明该年龄组是aa相关死亡率增加的重要危险因素。在国家层面,ASDR最高的三个国家是亚美尼亚、黑山和瑙鲁,而ASDR最低的三个国家是沙特阿拉伯、塔吉克斯坦和阿富汗。预测分析表明,虽然与aa有关的死亡人数预计将继续上升,但死亡率预计将下降。结论:虽然预计全球AA死亡人数将继续增加,但由于医疗保健的进步和早期干预的改进,ASDR总体上正在下降。然而,国家和SDI地区之间存在显著差异。在低SDI和中低SDI区域,ASDR继续上升,而在高SDI和中高SDI区域,ASDR稳步下降,但仍高于低SDI区域。因此,在全球范围内,对高危人群进行早期筛查和有效管理至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.80
自引率
11.10%
发文量
3529
审稿时长
14 weeks
期刊介绍: Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.
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