Sexual selection and pseudogenization in primate fertilization.

IF 3.1 2区 环境科学与生态学 Q2 ECOLOGY
Evolution Pub Date : 2025-06-05 DOI:10.1093/evolut/qpaf072
Jolie A Carlisle, Andrew L Bickell, Michael W Hart
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引用次数: 0

Abstract

The mouse sperm protein ZP3R interacts with proteins in the egg coat and mediates sperm-egg adhesion in a species-specific manner. Understanding the function and evolution of such genes has important implications for studies of speciation, reproductive success, and infertility. A recent analysis showed that (1) the human pseudogene C4BPAP1 is the ortholog of Zp3r, (2) ZP3R pseudogenization evolved independently in parallel among several primate lineages, and (3) functional ZP3R genes evolve under positive selection among other primate species. The causes of this pseudogenization of ZP3R are unknown. To explore one plausible cause (changes in sexual selection on males), we searched for ZP3R pseudogenes in recently published genomes, then compared sexually selected male traits among lineages with and without a functional ZP3R. We found that traits associated with more intense sexual selection on males (larger male body size, larger male canines, larger testes) were associated with functional ZP3R expression, and suggest that a relaxation of sexual selection may be associated with ZP3R pseudogenization. We propose the causal relationship implies an evolutionary cost to maintaining redundancy in the suite of primate fertilization genes.

灵长类动物受精中的性选择和假胚化。
小鼠精子蛋白ZP3R与卵膜蛋白相互作用,并以一种物种特异性的方式介导精子-卵子粘附。了解这些基因的功能和进化对物种形成、繁殖成功和不育的研究具有重要意义。最近的研究表明:(1)人类假基因C4BPAP1是Zp3r的同源基因;(2)Zp3r假基因在多个灵长类谱系中独立平行进化;(3)Zp3r功能基因在其他灵长类物种间的正选择下进化。ZP3R伪原化的原因尚不清楚。为了探索一个合理的原因(雄性性选择的变化),我们在最近发表的基因组中搜索了ZP3R假基因,然后比较了具有和不具有功能ZP3R的谱系的性选择男性特征。我们发现,与雄性更强烈的性选择相关的性状(雄性体型更大、雄性犬科动物更大、雄性睾丸更大)与ZP3R的功能性表达相关,这表明性选择的放松可能与ZP3R假原化有关。我们提出因果关系意味着维持灵长类受精基因套件冗余的进化成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Evolution
Evolution 环境科学-进化生物学
CiteScore
5.00
自引率
9.10%
发文量
0
审稿时长
3-6 weeks
期刊介绍: Evolution, published for the Society for the Study of Evolution, is the premier publication devoted to the study of organic evolution and the integration of the various fields of science concerned with evolution. The journal presents significant and original results that extend our understanding of evolutionary phenomena and processes.
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