Underreporting of Sex-Specific Findings in Risk Factors for Unruptured Intracranial Aneurysms.

IF 1.5 3区医学 Q3 CLINICAL NEUROLOGY

Cerebrovascular Diseases Pub Date : 2025-06-05 DOI:10.1159/000546774

Maaike J A van Eldik, Mariam Ali, Stijn Rietkerken, Sanne A E Peters, Hester M den Ruijter, Ynte M Ruigrok

{"title":"Underreporting of Sex-Specific Findings in Risk Factors for Unruptured Intracranial Aneurysms.","authors":"Maaike J A van Eldik, Mariam Ali, Stijn Rietkerken, Sanne A E Peters, Hester M den Ruijter, Ynte M Ruigrok","doi":"10.1159/000546774","DOIUrl":null,"url":null,"abstract":"Introduction: Women are overrepresented in the unruptured intracranial aneurysm (UIA) population, with an overall two-thirds of patients being female. The reasons behind this female preponderance are still unclear. Therefore, we performed a systematic review of clinical risk factors for UIA, with a specific aim of assessing whether these risk factor associations are sex-dependent.Methods: We systematically searched 5 electronic medical databases for all relevant literature up to March 2024. Cohort and case-control studies reporting on the lifestyle factors smoking, alcohol use, hypertension, hypercholesterolemia, physical activity, diabetes, and BMI were included.Results: We found a total of 21 studies, reporting on 347,907 participants and 8,698 UIA cases, that met our inclusion criteria. However, only one study provided its results stratified by sex, making it impossible to perform sex-stratified analyses.Conclusion: Our findings illustrate the scarcity of sex-stratified results in studies on risk factors for UIAs. Since knowledge on potential sex differences in UIA could help understand the female predominance, we highlight a need for more sex-stratified research in this field.","PeriodicalId":9683,"journal":{"name":"Cerebrovascular Diseases","volume":" ","pages":"1-5"},"PeriodicalIF":1.5000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233983/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cerebrovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546774","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Women are overrepresented in the unruptured intracranial aneurysm (UIA) population, with an overall two-thirds of patients being female. The reasons behind this female preponderance are still unclear. Therefore, we performed a systematic review of clinical risk factors for UIA, with a specific aim of assessing whether these risk factor associations are sex-dependent.

Methods: We systematically searched 5 electronic medical databases for all relevant literature up to March 2024. Cohort and case-control studies reporting on the lifestyle factors smoking, alcohol use, hypertension, hypercholesterolemia, physical activity, diabetes, and BMI were included.

Results: We found a total of 21 studies, reporting on 347,907 participants and 8,698 UIA cases, that met our inclusion criteria. However, only one study provided its results stratified by sex, making it impossible to perform sex-stratified analyses.

Conclusion: Our findings illustrate the scarcity of sex-stratified results in studies on risk factors for UIAs. Since knowledge on potential sex differences in UIA could help understand the female predominance, we highlight a need for more sex-stratified research in this field.

查看原文本刊更多论文

未破裂颅内动脉瘤危险因素的性别特异性发现少报。

在未破裂颅内动脉瘤（UIA）人群中，女性的比例过高，其中三分之二的患者为女性。这种女性优势背后的原因尚不清楚。因此，我们对UIA的临床危险因素进行了系统回顾，目的是评估这些危险因素是否与性别相关。方法：系统检索5个电子医学数据库，检索截至2024年3月的所有相关文献。报告生活方式因素的队列和病例对照研究包括吸烟、饮酒、高血压、高胆固醇血症、体育活动、糖尿病和BMI。结果：我们共发现21项研究，报告了347,907名参与者和8,698例UIA病例，符合我们的纳入标准。然而，21项研究中只有一项(结论：我们的研究结果表明，在尿路感染的危险因素研究中，缺乏性别分层的结果。由于了解UIA的潜在性别差异有助于理解女性优势，我们强调需要在这一领域进行更多的性别分层研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.