Impact of Poly-L-Lactic Acid Reconstitution on the Neocollagenesis Profile.

IF 2 3区医学 Q2 SURGERY

Aesthetic Plastic Surgery Pub Date : 2025-06-05 DOI:10.1007/s00266-025-04970-1

Janaína Motta Guerra, Maria Carolina Portela Albuquerque, Clarice Lioba de Araújo, Júlia Gonçalves Montenegro, Diana Araújo Cunha, Fabrício Bitu Sousa, Paulo Goberlânio de Barros Filho, Átila Vinícius Vitor Nobre

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引用次数: 0

Abstract

Purpose: The objective of the present work was to evaluate the percentage of neocollagenesis induction of the Sculptra^® in different forms of reconstitution.

Methods: For this, 150 male Swiss mice were used to which saline solution or reconstituted Sculptra^® were applied to the back subcutaneous tissue immediately before application (0 h), 2, 24 or 72 h before administration and were euthanized after 15, 30 and 60 days of administration of the material in a number of 10/group/day. Their backs were removed for histological analysis and immunoexpression for alpha-smooth muscle actin (α-SMA). The data was statistically analyzed (p < 0.05).

Results: After 30 days of administration, the Sculptra^® 72 h group showed greater collagen formation than the control (p = 0.016) and 0h groups (p = 0.023). After 60 days, the Sculptra^® 24 and 72 h groups also showed greater collagen formation than the control (p = 0.025) and 0 h groups ( p = 0.039). After 30 days of administration, the Sculptra^® 24 and 72 h groups showed higher immunoexpression for α-SMA (p = 0.001), as well as after 60 days (p < 0.001).

Conclusions: We can conclude that Sculptra^® reconstituted 2, 24 and 72 h before its application has the potential to induce collagen after 60 days. Furthermore, there is greater expression of α-SMA after reconstitution 24 and 72 h before Sculptra^® injection, after 30 and 60 days. No level of evidence is needed for Basic Science, Animal Study, Cadaver Study, and Experimental Study Articles.

No level assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

查看原文本刊更多论文

聚l -乳酸重构对新胶原形成的影响。

目的：本研究的目的是评估不同重建形式下Sculptra®诱导新胶原形成的百分比。方法：为此，150只雄性瑞士小鼠在给药前立即（0小时）、给药前2、24或72小时将生理盐水溶液或重组的Sculptra®涂于背部皮下组织，并在给药15、30和60天后以10只/组/天的方式安乐死。切除小鼠背部，进行组织学分析和α-平滑肌肌动蛋白免疫表达。结果：给药30天后，Sculptra®72 h组的胶原形成量高于对照组（p = 0.016）和0h组（p = 0.023）。60天后，Sculptra®24和72 h组也比对照组（p = 0.025）和0 h组（p = 0.039）显示出更多的胶原形成。在给药30天后和60天后，Sculptra®24和72 h组α-SMA的免疫表达更高（p = 0.001）。结论：我们可以得出，在给药前2、24和72 h重建的Sculptra®在60天后具有诱导胶原的潜力。此外，注射Sculptra®前24、72 h、30、60 d重建后α-SMA的表达量更高。基础科学、动物研究、尸体研究和实验研究文章不需要任何水平的证据。未指定水平：本刊要求作者为每份投稿指定证据水平，以适用循证医学排名。这不包括评论文章、书评和涉及基础科学、动物研究、尸体研究和实验研究的手稿。有关这些循证医学评级的完整描述，请参阅目录或在线作者说明www.springer.com/00266。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aesthetic Plastic Surgery 医学-外科

CiteScore

4.40

自引率

25.00%

发文量

479

审稿时长

3 months

期刊介绍： Aesthetic Plastic Surgery is a publication of the International Society of Aesthetic Plastic Surgery and the official journal of the European Association of Societies of Aesthetic Plastic Surgery (EASAPS), Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica (SICPRE), Vereinigung der Deutschen Aesthetisch Plastischen Chirurgen (VDAPC), the Romanian Aesthetic Surgery Society (RASS), Asociación Española de Cirugía Estética Plástica (AECEP), La Sociedad Argentina de Cirugía Plástica, Estética y Reparadora (SACPER), the Rhinoplasty Society of Europe (RSE), the Iranian Society of Plastic and Aesthetic Surgeons (ISPAS), the Singapore Association of Plastic Surgeons (SAPS), the Australasian Society of Aesthetic Plastic Surgeons (ASAPS), the Egyptian Society of Plastic and Reconstructive Surgeons (ESPRS), and the Sociedad Chilena de Cirugía Plástica, Reconstructiva y Estética (SCCP). Aesthetic Plastic Surgery provides a forum for original articles advancing the art of aesthetic plastic surgery. Many describe surgical craftsmanship; others deal with complications in surgical procedures and methods by which to treat or avoid them. Coverage includes "second thoughts" on established techniques, which might be abandoned, modified, or improved. Also included are case histories; improvements in surgical instruments, pharmaceuticals, and operating room equipment; and discussions of problems such as the role of psychosocial factors in the doctor-patient and the patient-public interrelationships. Aesthetic Plastic Surgery is covered in Current Contents/Clinical Medicine, SciSearch, Research Alert, Index Medicus-Medline, and Excerpta Medica/Embase.