{"title":"An analysis of epidemiological characteristics of microvascular complications and comorbidities among type 1 diabetes patients.","authors":"Małgorzata Lewicka, Irmina Korzeniowska-Dyl, Dariusz Moczulski, Agnieszka Woźniak-Kosek, Magdalena Zawadzka, Gabriela Henrykowska","doi":"10.3389/abp.2025.14569","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Epidemiological analysis of medical data of patients with type 1 diabetes (T1DM) and disease complications treated in hospital.</p><p><strong>Methods: </strong>A retrospective, cross-sectional study was conducted on records from 306 patients with type 1 diabetes (180 men and 126 women). The study analyzed demographic, clinical, and biological data, focusing on associations between Hashimoto's disease, neuropathy, and retinopathy using k-means clustering.</p><p><strong>Results: </strong>Hypertension was present in 28.8%, Hashimoto's disease in 17.6%, retinopathy in 17.6%, neuropathy in 8.2%. Multivariate logistic regression showed that the chance of retinopathy more than doubles with the coexistence of hypertension (OR 2.096, 95% Cl: 1.035-4.248) and this chance increases by 4.5% with each year of age compared to the previous year (OR 1.045, 95% Cl: 1.011-1.080). The risk of neuropathy increases by 10.8% with each year since diabetes diagnosis compared to the previous year (OR = 1.108, 95% Cl: 1.062-1.156) and the chance of this disease rises by 17.6% with each year of diabetes duration compared to the previous year (OR 1.176, 95% Cl: 1.092-1.267). Clustering was strongest in patients without comorbidities (66.3%). Only 2.3% had Hashimoto's disease and retinopathy, 3.59% had retinopathy and neuropathy, and just 1.3% had all three conditions.</p><p><strong>Conclusion: </strong>Patient age, duration of diabetes, and the presence of hypertension are key risk factors for diabetes-related complication.</p>","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":"72 ","pages":"14569"},"PeriodicalIF":1.4000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137067/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta biochimica Polonica","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/abp.2025.14569","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: Epidemiological analysis of medical data of patients with type 1 diabetes (T1DM) and disease complications treated in hospital.
Methods: A retrospective, cross-sectional study was conducted on records from 306 patients with type 1 diabetes (180 men and 126 women). The study analyzed demographic, clinical, and biological data, focusing on associations between Hashimoto's disease, neuropathy, and retinopathy using k-means clustering.
Results: Hypertension was present in 28.8%, Hashimoto's disease in 17.6%, retinopathy in 17.6%, neuropathy in 8.2%. Multivariate logistic regression showed that the chance of retinopathy more than doubles with the coexistence of hypertension (OR 2.096, 95% Cl: 1.035-4.248) and this chance increases by 4.5% with each year of age compared to the previous year (OR 1.045, 95% Cl: 1.011-1.080). The risk of neuropathy increases by 10.8% with each year since diabetes diagnosis compared to the previous year (OR = 1.108, 95% Cl: 1.062-1.156) and the chance of this disease rises by 17.6% with each year of diabetes duration compared to the previous year (OR 1.176, 95% Cl: 1.092-1.267). Clustering was strongest in patients without comorbidities (66.3%). Only 2.3% had Hashimoto's disease and retinopathy, 3.59% had retinopathy and neuropathy, and just 1.3% had all three conditions.
Conclusion: Patient age, duration of diabetes, and the presence of hypertension are key risk factors for diabetes-related complication.
期刊介绍:
Acta Biochimica Polonica is a journal covering enzymology and metabolism, membranes and bioenergetics, gene structure and expression, protein, nucleic acid and carbohydrate structure and metabolism.