An analysis of epidemiological characteristics of microvascular complications and comorbidities among type 1 diabetes patients.

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Acta biochimica Polonica Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.3389/abp.2025.14569
Małgorzata Lewicka, Irmina Korzeniowska-Dyl, Dariusz Moczulski, Agnieszka Woźniak-Kosek, Magdalena Zawadzka, Gabriela Henrykowska
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Abstract

Purpose: Epidemiological analysis of medical data of patients with type 1 diabetes (T1DM) and disease complications treated in hospital.

Methods: A retrospective, cross-sectional study was conducted on records from 306 patients with type 1 diabetes (180 men and 126 women). The study analyzed demographic, clinical, and biological data, focusing on associations between Hashimoto's disease, neuropathy, and retinopathy using k-means clustering.

Results: Hypertension was present in 28.8%, Hashimoto's disease in 17.6%, retinopathy in 17.6%, neuropathy in 8.2%. Multivariate logistic regression showed that the chance of retinopathy more than doubles with the coexistence of hypertension (OR 2.096, 95% Cl: 1.035-4.248) and this chance increases by 4.5% with each year of age compared to the previous year (OR 1.045, 95% Cl: 1.011-1.080). The risk of neuropathy increases by 10.8% with each year since diabetes diagnosis compared to the previous year (OR = 1.108, 95% Cl: 1.062-1.156) and the chance of this disease rises by 17.6% with each year of diabetes duration compared to the previous year (OR 1.176, 95% Cl: 1.092-1.267). Clustering was strongest in patients without comorbidities (66.3%). Only 2.3% had Hashimoto's disease and retinopathy, 3.59% had retinopathy and neuropathy, and just 1.3% had all three conditions.

Conclusion: Patient age, duration of diabetes, and the presence of hypertension are key risk factors for diabetes-related complication.

1型糖尿病患者微血管并发症及合并症的流行病学特征分析。
目的:对住院治疗的1型糖尿病(T1DM)患者的医疗资料及并发症进行流行病学分析。方法:对306例1型糖尿病患者(男性180例,女性126例)进行回顾性横断面研究。该研究分析了人口统计学、临床和生物学数据,重点关注桥本氏病、神经病变和视网膜病变之间的关联。结果:高血压28.8%,桥本氏病17.6%,视网膜病变17.6%,神经病变8.2%。多因素logistic回归分析显示,伴有高血压的患者视网膜病变的几率增加一倍以上(OR 2.096, 95% Cl: 1.035 ~ 4.248),且随年龄的增长,视网膜病变的几率比前一年增加4.5% (OR 1.045, 95% Cl: 1.011 ~ 1.080)。自糖尿病诊断以来,神经病变的风险与前一年相比每年增加10.8% (OR = 1.108, 95% Cl: 1.062-1.156),该疾病的机会与前一年相比每年增加17.6% (OR = 1.176, 95% Cl: 1.092-1.267)。聚集性最强的是无合并症的患者(66.3%)。只有2.3%的人患有桥本氏病和视网膜病变,3.59%的人患有视网膜病变和神经病变,只有1.3%的人同时患有这三种疾病。结论:患者年龄、糖尿病病程、是否存在高血压是发生糖尿病相关并发症的关键危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta biochimica Polonica
Acta biochimica Polonica 生物-生化与分子生物学
CiteScore
2.40
自引率
0.00%
发文量
99
审稿时长
4-8 weeks
期刊介绍: Acta Biochimica Polonica is a journal covering enzymology and metabolism, membranes and bioenergetics, gene structure and expression, protein, nucleic acid and carbohydrate structure and metabolism.
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