Visual Diagnostic Strategy for Assessing the Impact of Aerobic Glycolytic Processes on Tumor Growth and Therapy.

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-06-06 DOI:10.1021/acs.nanolett.5c01784

Shiqi Wang, Jiaqing Guo, Yixuan Yang, Ping Lu, Zhaoyuan Zhang, Shijun Huang, Ye Fang, Hui Zhang, Han Zhang, Wenhui Yu, Junle Qu, Liwei Liu

引用次数: 0

Abstract

Investigating the role of nicotinamide phosphoribosyltransferase (NAMPT) in tumor growth is significant for enhancing cancer treatment outcomes. This work proposes fluorescence lifetime endoscopic microscopy (FLIME) for the real-time visualization of aerobic glycolysis in the tumor microenvironment. We investigated the effect of NAMPT inhibition using the FK866 small-molecule inhibitor in a mouse model. The results show that FK866 effectively inhibits the NAD+-induced aerobic glycolysis process and decelerates tumor growth. Moreover, the combined effect of FK866 with cisplatin can further inhibit tumor proliferation and progression. These findings indicate that the acidity of the tumor microenvironment can serve as a metric for evaluating the extent of aerobic glycolysis and its implications for tumor growth and treatment, offering a potentially valuable approach for assessing clinical drug efficacy.

Abstract Image

查看原文本刊更多论文

评估有氧糖酵解过程对肿瘤生长和治疗影响的视觉诊断策略。

研究烟酰胺磷酸核糖基转移酶（NAMPT）在肿瘤生长中的作用对提高癌症治疗效果具有重要意义。这项工作提出了荧光寿命内窥镜（FLIME）用于肿瘤微环境中有氧糖酵解的实时可视化。我们在小鼠模型中研究了FK866小分子抑制剂对NAMPT的抑制作用。结果表明，FK866能有效抑制NAD+诱导的有氧糖酵解过程，减缓肿瘤生长。此外，FK866联合顺铂可进一步抑制肿瘤的增殖和进展。这些发现表明，肿瘤微环境的酸度可以作为评估有氧糖酵解程度及其对肿瘤生长和治疗的影响的指标，为评估临床药物疗效提供了一种潜在的有价值的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.