A Bench-Stable Fluorophosphine Nickel(0) Complex and Its Catalytic Application

Angewandte Chemie Pub Date : 2025-04-09 DOI:10.1002/ange.202506271

Franziska Flecken, Arjun Neyyathala, Toni Grell, Schirin Hanf

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Abstract

We herein present a fluorophosphine-based nickel(0) complex [Ni(PFPh₂)₄] (1), which is highly stable in air and water. [Ni(PFPh₂)₄] can be obtained from a one-pot reaction of [Ni(MeCN)₄](BF₄)₂ with Ph₂P(═O)–PPh₂, involving a unique in situ reduction of Ni(II) to Ni(0) and a simultaneous fluorination by the BF₄⁻ anion. This complex does not only incorporate a nickel center in the zero-oxidation state, resulting from a Ni(II) precursor, but also includes fluorophosphine ligands, which typically disproportionate immediately in solution. The application of [Ni(PFPh₂)₄] as highly stable Ni(0) pre-catalyst in combination with additional phosphine ligands, such as dppf (1,1′-bis(diphenylphosphino)ferrocene), in various coupling reactions uncovers its high catalytic activity and versatility, which is superior to [Ni(COD)₂] (COD═cycloocta-1,5-diene) as conventional Ni(0) source.

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一种稳定的氟膦镍配合物及其催化应用

本文提出了一种氟膦基镍(0)配合物[Ni(PFPh2)4](1)，该配合物在空气和水中具有很高的稳定性。[Ni(PFPh2)4]可以由[Ni(MeCN)4](BF4)2与Ph2P(= O) -PPh2的一锅反应得到，包括Ni（II）在原位还原为Ni(0)和同时由BF4−阴离子氟化。该配合物不仅包含由Ni（II）前体产生的处于零氧化态的镍中心，而且还包括氟膦配体，其通常在溶液中立即不成比例。[Ni(PFPh2)4]作为高度稳定的Ni(0)预催化剂与附加的膦配体(如dppf（1,1 ' -双（二苯基膦）二茂铁）结合在各种偶联反应中的应用，揭示了它的高催化活性和多功能性，优于[Ni(COD)2] （COD =环-1,5-二烯）作为传统Ni(0)源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angewandte Chemie 化学科学, 有机化学, 有机合成

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0.00%

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审稿时长

1 months