Biomechanical study on the effect of changes in ostiomeatal complex structure on NO concentration in the nasal cavity

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nitric oxide : biology and chemistry Pub Date : 2025-06-04 DOI:10.1016/j.niox.2025.06.001

Shen Yu , Xiaojun Xie , Danqing Wang , Yan Guo , Jizhe Wang

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引用次数: 0

Abstract

Background

Nitric oxide (NO) concentration in the nasal cavity plays an important role in maintaining nasal function and health. We investigated the influence of the geometric structure of the ostiomeatal complex (OMC) on nasal cavity NO concentration distribution and provide optimization strategies for reconstruction surgery related to OMC function.

Method

ology: Numerical nasal cavity models of 21 healthy volunteers were established, and the effects of the OMC structure on NO distribution in the nasal cavity were numerically studied. Additionally, the nasal meatus widths of five healthy adult New Zealand rabbits were modified surgically. Exhaled NO concentration was measured pre- and post-surgery to study the effect of nasal meatus width on NO distribution in the rabbit nasal cavities.

Results

Through numerical analysis, a quantified relationship was obtained between the width of the middle nasal passage, the hydraulic diameter of the maxillary sinus ostium, and airflow rate with the concentration of NO in the nasal and paranasal sinuses. The impact of these three factors on the NO concentration of exhaled airflow was compared across all volunteers. An optimal combination of middle nasal passage width and ostium diameter can ensure a normal NO concentration in the nasal cavity.

Conclusions

When reconstructing the OMC structure to restore function, factors such as the width of the middle nasal meatus and maxillary sinus ostium area and length should be considered comprehensively to reshape an optimal OMC structure for achieving a normal physiological distribution of NO concentration in the nasal cavity.

查看原文本刊更多论文

口鼻道复合体结构变化对鼻腔NO浓度影响的生物力学研究

鼻腔内一氧化氮（NO）浓度在维持鼻腔功能和健康中起着重要作用。我们研究了口鼻道复合体（OMC）的几何结构对鼻腔NO浓度分布的影响，并为OMC功能相关的重建手术提供优化策略。方法：建立21例健康志愿者鼻腔数值模型，数值研究OMC结构对鼻腔NO分布的影响。另外，对5只健康成年新西兰兔的鼻道宽度进行了手术修饰。术前、术后测定兔呼出一氧化氮浓度，研究鼻道宽度对兔鼻腔内一氧化氮分布的影响。结果通过数值分析，得到了鼻中通道宽度、上颌窦口水力直径、气流速率与鼻、鼻窦NO浓度之间的定量关系。比较了这三个因素对所有志愿者呼出气流中NO浓度的影响。鼻中通道宽度和鼻孔直径的最佳组合可以保证鼻腔内正常的NO浓度。结论在重建OMC结构以恢复功能时，应综合考虑鼻中道宽度和上颌窦口面积、长度等因素，重塑最佳的OMC结构，使鼻腔内NO浓度达到正常的生理分布。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nitric oxide : biology and chemistry 生物-生化与分子生物学

CiteScore

7.50

自引率

7.70%

发文量

审稿时长

52 days

期刊介绍： Nitric Oxide includes original research, methodology papers and reviews relating to nitric oxide and other gasotransmitters such as hydrogen sulfide and carbon monoxide. Special emphasis is placed on the biological chemistry, physiology, pharmacology, enzymology and pathological significance of these molecules in human health and disease. The journal also accepts manuscripts relating to plant and microbial studies involving these molecules.