mRNA translational control of regeneration

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-06-07 DOI:10.1016/j.gde.2025.102367

Mehdi Amiri , Nahum Sonenberg , Soroush Tahmasebi

引用次数: 0

Abstract

mRNA translation is rapidly upregulated after injury to supply proteins required for tissue regeneration. Augmented protein synthesis during regeneration has long been associated with increases in ribosome biogenesis and mTORC1 activity. Emerging evidence highlights the roles of multiple signaling pathways, RNA-binding proteins, and RNA modifications in tissue repair. Here, we review recent research on the molecular mechanisms underlying translational control in response to tissue damage. The findings underscore the importance of mRNA translation in regeneration and its potential therapeutic applications in tissue repair.

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再生的mRNA翻译控制

mRNA翻译在损伤后迅速上调，以提供组织再生所需的蛋白质。长期以来，再生过程中蛋白质合成的增强与核糖体生物发生和mTORC1活性的增加有关。新出现的证据强调了多种信号通路、RNA结合蛋白和RNA修饰在组织修复中的作用。在这里，我们回顾了最近在组织损伤反应中翻译控制的分子机制方面的研究。这些发现强调了mRNA翻译在再生中的重要性及其在组织修复中的潜在治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)