Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways

IF 3.7 2区 生物学 Q2 CELL BIOLOGY
Wenxin Xie , Manjunath Gowder , Dominic Bazzano , Morgan DeSantis , Saher S Hammoud
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引用次数: 0

Abstract

Meiotic prophase movement and chromosome bouquet formation are highly conserved processes and essential features of meiosis, yet their functional components and dependencies vary among organisms. A key feature of meiotic prophase is that chromosome regions like telomeres or centromeres become physically tethered to the inner nuclear membrane through a hierarchical and sequential arrangement of proteins. Telomeres or their analogs further interact with the cytoskeletal machinery, which provides the necessary mechanical force to execute the chromosomal movements that enable homologous pairing, synapsis, and meiotic recombination. Despite decades of research, our understanding of these processes, their interdependencies, and their precise role remains incomplete. Here, we summarize the current mechanistic understanding and describe avenues for further exploration.
减数分裂前期运动的重新布线:调节因子,角色和进化途径
减数分裂前期运动和染色体束形成是减数分裂高度保守的过程,是减数分裂的基本特征,但它们的功能成分和依赖关系在不同生物中有所不同。减数分裂前期的一个关键特征是染色体区域,如端粒或着丝粒,通过蛋白质的分层和顺序排列,在物理上与核膜相连。端粒或它们的类似物进一步与细胞骨架机制相互作用,提供必要的机械力来执行染色体运动,使同源配对、突触和减数分裂重组成为可能。尽管经过了几十年的研究,我们对这些过程、它们的相互依赖性以及它们的确切作用的理解仍然不完整。在这里,我们总结了目前的机制理解,并描述了进一步探索的途径。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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