Evaluation of the impact of reducing fasting hours on laboratory results in a mediterranean population.

Biochemia medica Pub Date : 2025-06-15 Epub Date: 2025-04-15 DOI:10.11613/BM.2025.020703
Gemma Solé-Enrech, Ruth Cano-Corres, Raquel Escribano-Tembleque, Eva Martínez-Sevilla, Núria Busquets-Carmona, Carlos García-Miralles
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Abstract

Introduction: One of the critical points of the preanalytical phase is the patient's adherence to the required fasting duration before undergoing medical analysis. Although many laboratories have already protocols for blood-sample collection that require only a 6-hour fast, clinical guidelines remain unclear on this aspect, and fasting periods of 12 hours are sometimes still recommended. The aim of this study was to evaluate whether there are significant differences between the results obtained in patients' serum samples obtained post-fasting, 4 hours post-meal, and 6 hours post-meal for different predetermined parameters.

Materials and methods: 30 volunteers (16 females and 14 males) aged between 23 and 62 years were selected for this study. Each participant underwent an initial analysis after a 10-hour fast (baseline), a second analysis 4 hours after a controlled meal, and a third analysis 6 hours after the meal. The parameters studied correspond to previously selected biochemical, hematological, and coagulation tests. To assess if there are significant differences in the results obtained for each analyte, criteria based on the total allowable error (TEa) and the reference change value (RCV) were used.

Results: All parameters evaluated in this study met the criteria based on the RCV at both 4 and 6 hours, although some parameters did not meet TEa criteria.

Conclusions: The results obtained in this study demonstrated that a fasting period of 4 or 6 hours is sufficient to obtain reliable results. This could significantly improve the quality of life for patients undergoing analysis without compromising the quality of their results.

评估地中海人群减少禁食时间对实验室结果的影响。
分析前阶段的关键点之一是患者在接受医学分析前坚持所需的禁食时间。尽管许多实验室已经制定了只需要禁食6小时的血样采集方案,但临床指南在这方面仍不明确,有时仍建议禁食12小时。本研究的目的是评估空腹后、餐后4小时和餐后6小时的患者血清样本在不同预定参数下的结果是否存在显著差异。材料与方法:本研究选取30名志愿者,其中女性16名,男性14名,年龄在23 ~ 62岁之间。每位参与者在禁食10小时(基线)后进行初步分析,在控制饮食后4小时进行第二次分析,在用餐后6小时进行第三次分析。所研究的参数与先前选定的生化、血液学和凝血试验相对应。为了评估每种分析物获得的结果是否存在显著差异,使用基于总允许误差(TEa)和参考变化值(RCV)的标准。结果:本研究评估的所有参数均符合基于4和6小时RCV的标准,尽管一些参数不符合TEa标准。结论:本研究结果表明,禁食4或6小时足以获得可靠的结果。这可以显著改善接受分析的患者的生活质量,而不会影响结果的质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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