The application progress of cell membrane biomimetic nanoparticles in cancer diagnosis and treatment1

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology Pub Date : 2025-06-02 DOI:10.1016/j.pbiomolbio.2025.05.004

Baiyan Wang , Jiayi Li , Dandan Guo , Shuxuan Li , Yalan Li , Qianqian Wang , Yi Yang , Wei Chen , Shuying Feng

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Abstract

Cancer diagnosis and treatment remains challenging, with unresolved issues such as low targeting, drug resistance, and numerous adverse reactions from chemotherapy. Cell membrane biomimetic modified nanoparticles(CMBMNPs), wrapping cell membrane on nanoparticles can achieve homologous cell mimicry, so that it can obtain the functions and properties of the type of cell, with strong targeting ability, strong immune evasion ability, long in vivo circulation time, etc., which is getting more and more attention. This article describes the preparation process of CMBMNPs and the different clinical effects of different types of nanoparticles and mimicking cell membranes in order to select the right match for use. In addition, we list in detail several important features of CMBMNPs as well as the advantages of CMBMNPs in areas related to cancer diagnosis and therapy, and look forward to the future challenges and prospects of cell membrane-generating nanotechnology, which provides new insights into the application of CMBMNPs in cancer diagnosis and therapy.

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细胞膜仿生纳米颗粒在肿瘤诊断与治疗中的应用进展

癌症的诊断和治疗仍然具有挑战性，如低靶向性、耐药性和化疗的众多不良反应等尚未解决的问题。细胞膜仿生修饰纳米颗粒（CMBMNPs），在纳米颗粒上包裹细胞膜可以实现同源细胞的模仿，使其能够获得细胞类型的功能和特性，具有靶向能力强、免疫逃避能力强、体内循环时间长等特点，越来越受到人们的关注。本文介绍了CMBMNPs的制备过程，以及不同类型的纳米颗粒和模拟细胞膜的不同临床效果，以便选择合适的配型使用。此外，我们详细列出了CMBMNPs的几个重要特性以及CMBMNPs在癌症诊断和治疗相关领域的优势，并展望了未来膜生成纳米技术的挑战和前景，为CMBMNPs在癌症诊断和治疗中的应用提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Biophysics & Molecular Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

7.90%

发文量

审稿时长

85 days

期刊介绍： Progress in Biophysics & Molecular Biology is an international review journal and covers the ground between the physical and biological sciences since its launch in 1950. It indicates to the physicist the great variety of unsolved problems awaiting attention in biology and medicine. The biologist and biochemist will find that this journal presents new and stimulating ideas and novel approaches to studying and influencing structural and functional properties of the living organism. This journal will be of particular interest to biophysicists, biologists, biochemists, cell physiologists, systems biologists, and molecular biologists.