Trends in the epidemiology of extended-spectrum beta-lactamase-producing Enterobacterales – Boulder County, Colorado, 2020–2022

IF 3 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals of Epidemiology Pub Date : 2025-06-02 DOI:10.1016/j.annepidem.2025.06.001

Alyssa Beck , Jennifer Driscoll , Karlie Hoetzer , Deborah Hindman , Keith Rawls , Janell , Helen Johnston , Christopher A. Czaja

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引用次数: 0

Abstract

Purpose

Extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) are serious antibiotic resistance threats. We describe trends in epidemiological and clinical characteristics of ESBL-E cases in Boulder County, Colorado from 2020 to 2022.

Methods

The Colorado Department of Public Health and Environment (CDPHE) and Boulder County Public Health conduct population-based surveillance for ESBL-E as part of the Emerging Infections Program-Healthcare-Associated Infections Community Interface. Trained epidemiologists abstracted data from patient medical records from the year prior to incident specimen collection through 30 days after.

Results

There were 1036 ESBL-E cases. Annual case counts increased from 2020 to 2022 (256, 316, and 464, respectively). The rate of ESBL-E infections per 100,000 population increased (77.4 in 2020, 96.6 in 2021, and 141.7 in 2022). Most samples were collected from outpatient settings (n = 812, 92.2 %) and Escherichia coli was the most common organism identified (n = 789, 89.6 %). Most case-patients had a lower urinary tract infection (UTI) (n = 757, 85.9 %), which increased by year (p = 0.03).

Conclusions

ESBL-E counts and incidence rates in Boulder County increased from 2020 to 2022. Cases most commonly presented with E. coli urinary tract infections in the outpatient setting. Strategies to combat antibiotic resistance should target ESBL-E in community settings.

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广谱产β -内酰胺酶肠杆菌的流行病学趋势——科罗拉多州博尔德县，2020-2022。

目的：产广谱β -内酰胺酶肠杆菌（ESBL-E）是严重的抗生素耐药威胁。我们描述了2020-2022年科罗拉多州博尔德县ESBL-E病例的流行病学和临床特征趋势。方法：科罗拉多州公共卫生与环境部门（CDPHE）和博尔德县公共卫生部门对ESBL-E进行基于人群的监测，作为新发感染项目卫生保健相关感染社区接口的一部分。训练有素的流行病学家从患者的医疗记录中提取数据，从事件前一年的标本采集到事件后30天。结果：ESBL-E 1036例。从2020年到2022年，年度病例数有所增加（分别为256例、316例和464例）。每10万人中ESBL-E感染率上升（2020年为77.4,2021年为96.6,2022年为141.7）。大多数样本来自门诊（n=812, 92.2%），大肠杆菌是最常见的细菌（n=789, 89.6%）。大多数患者发生下尿路感染（UTI）（n=757, 85.9%），且逐年增加（p=0.03）。结论：博尔德县ESBL-E计数和发病率从2020年到2022年有所增加。病例最常见的表现为大肠杆菌尿路感染在门诊设置。抗击抗生素耐药性的战略应以社区环境中的ESBL-E为目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.40

自引率

1.80%

发文量

207

审稿时长

59 days

期刊介绍： The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.