An international survey on measures to prevent transfusion-transmitted infectious diseases-study results 1: Participation rates and the presence of laws, regulations, standards and best practices.

IF 1.6 4区医学 Q3 HEMATOLOGY

Vox Sanguinis Pub Date : 2025-08-01 Epub Date: 2025-06-04 DOI:10.1111/vox.70057

Galen Conti, Jay Epstein, Silvano Wendel, Claude Tayou Tagny, Antoine Lewin, Divjot Singh Lamba, Lesley Bust, Chancelar Kafere, Jean Stanley, Maria Roussakis, Hany Kamel, Roger Y Dodd, Susan L Stramer

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Abstract

Background and objectives: A global survey on blood safety measures to prevent transfusion-transmitted infectious diseases (TTIDs) was performed by examining variations in current usage. This analysis focuses on participation rates and the presence of relevant laws, regulations, standards and best practices for collection/processing of whole blood/components.

Materials and methods: Distribution occurred between October 2023 and March 2024. States, provinces or cities within China and India were analysed as separate regions. Country/region (C/R) responses were categorized by World Bank income (WBI) levels: low- and lower middle-income (LLMI), upper middle-income (UMI) and high-income (HI). Consensus responses were used for multiple survey responses.

Results: Responses from 131 individuals representing 74 C/Rs (65 countries, Hong Kong, counted separately, and 8 regions in China/India) were analysed. Affirmative responses for laws, regulations and standards were similar across WBI levels. Regulatory jurisdiction for blood/components was present in 96% of C/Rs (HI 100%, UMI 100%, LLMI 87%) and 94% at a national level when present (HI 100%, UMI 94%, LLMI 85%). All HI, UMI and 74% LLMI C/Rs reported routinely separating whole blood into components. HI C/Rs were more likely to screen for bacterial contamination, whereas periodic platelet quality control was more common in LLMI and UMI C/Rs. Pathogen reduction and universal leukocyte reduction were more common in HI C/Rs.

Conclusion: Laws, regulations and standards for collection/processing of blood were consistent across WBI groups. Resource-intensive practices of blood component separation and use of advanced blood safety technologies were more variable, with less utilization in LLMI/UMI C/Rs.

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预防输血传播传染病措施的国际调查——研究结果1：参与率和法律、法规、标准和最佳做法的存在情况。

背景和目的：通过检查目前使用情况的变化，对预防输血传播传染病（TTIDs）的血液安全措施进行了全球调查。本分析的重点是参与率和收集/处理全血/成分的相关法律、法规、标准和最佳做法的存在情况。资料与方法：分布时间为2023年10月至2024年3月。中国和印度的州、省或城市被作为单独的区域进行分析。国家/地区（C/R）的反应按世界银行收入（WBI）水平分类：低收入和中低收入（LLMI）、中高收入（UMI）和高收入（HI）。共识回答用于多次调查回答。结果：来自74个C/Rs（65个国家，香港，单独计算，中国/印度8个地区）的131名个人的回复进行了分析。对法律、法规和标准的肯定回答在各WBI水平上是相似的。96%的C/Rs （HI 100%, UMI 100%, LLMI 87%）和94%的国家一级（HI 100%, UMI 94%, LLMI 85%）存在对血液/成分的监管管辖权。所有HI、UMI和74% LLMI C/Rs报告常规地将全血分离成组分。HI C/Rs更有可能筛查细菌污染，而周期性血小板质量控制在LLMI和UMI C/Rs中更常见。致病菌减少和白细胞普遍减少在HI - C/Rs中更为常见。结论：血液采集/处理的法律、法规和标准在WBI各组间是一致的。血液成分分离的资源密集型做法和先进血液安全技术的使用变化较大，LLMI/UMI C/Rs的利用率较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vox Sanguinis 医学-血液学

CiteScore

4.40

自引率

11.10%

发文量

156

审稿时长

6-12 weeks

期刊介绍： Vox Sanguinis reports on important, novel developments in transfusion medicine. Original papers, reviews and international fora are published on all aspects of blood transfusion and tissue transplantation, comprising five main sections: 1) Transfusion - Transmitted Disease and its Prevention: Identification and epidemiology of infectious agents transmissible by blood; Bacterial contamination of blood components; Donor recruitment and selection methods; Pathogen inactivation. 2) Blood Component Collection and Production: Blood collection methods and devices (including apheresis); Plasma fractionation techniques and plasma derivatives; Preparation of labile blood components; Inventory management; Hematopoietic progenitor cell collection and storage; Collection and storage of tissues; Quality management and good manufacturing practice; Automation and information technology. 3) Transfusion Medicine and New Therapies: Transfusion thresholds and audits; Haemovigilance; Clinical trials regarding appropriate haemotherapy; Non-infectious adverse affects of transfusion; Therapeutic apheresis; Support of transplant patients; Gene therapy and immunotherapy. 4) Immunohaematology and Immunogenetics: Autoimmunity in haematology; Alloimmunity of blood; Pre-transfusion testing; Immunodiagnostics; Immunobiology; Complement in immunohaematology; Blood typing reagents; Genetic markers of blood cells and serum proteins: polymorphisms and function; Genetic markers and disease; Parentage testing and forensic immunohaematology. 5) Cellular Therapy: Cell-based therapies; Stem cell sources; Stem cell processing and storage; Stem cell products; Stem cell plasticity; Regenerative medicine with cells; Cellular immunotherapy; Molecular therapy; Gene therapy.