Comparison of the effects of drug-coated balloon and bare metal stent in the treatment of lower extremity arteriosclerosis obliterans.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2025-05-01 DOI:10.12669/pjms.41.5.11520

Yu Zhang, Kefan Wang, Lijing Zhou, Nan Guo, Qingyou Chen, Yuanyuan Zhai

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引用次数: 0

Abstract

Objective: To compare the efficacy of drug-coated balloons (DCB) and bare metal stents (BMS) in treating lower extremity arteriosclerosis obliterans (LEASO).

Methods: Clinical data of 83 patients who underwent LEASO angioplasty with DCB or BMS at the Third Affiliated Hospital of Qiqihar Medical College from July 2021 to January 2024 were retrospectively analyzed. Patients were divided into the DCB (n=43) and BMS (n=40) groups based on the treatment method. Changes in ankle-brachial index (ABI), pulse volume recording (PVR), vascular endothelial function indicators, incidence of complications, and patency rate were compared between the two groups.

Results: Three months after the surgery, the ABI and nitric oxide (NO) levels in the DCB group were higher, while the upstroke time (UT), percentage of mean arterial pressure (%MAP), brachial-ankle pulse wave velocity (baPWV), and endothelin-1 (ET-1) levels were lower than those in the BMS group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). One year after the surgery, the patency rate of the DCB group was higher than that of the BMS group (P<0.05).

Conclusions: DCB treatment for LEASO is superior to BMS in improving vascular function, protecting endothelial function, and achieving a one-year patency rate.

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药物包被球囊与裸金属支架治疗下肢动脉硬化闭塞症的疗效比较。

目的：比较药物包被球囊（DCB）与裸金属支架（BMS）治疗下肢动脉硬化闭塞症（LEASO）的疗效。方法：回顾性分析2021年7月至2024年1月齐齐哈尔医学院第三附属医院行LEASO血管成形术的83例DCB或BMS患者的临床资料。根据治疗方法将患者分为DCB组（n=43）和BMS组（n=40）。比较两组踝肱指数（ABI）、脉搏容积记录（PVR）、血管内皮功能指标、并发症发生率、通畅率的变化。结果：术后3个月，DCB组ABI、一氧化氮（NO）水平均高于BMS组，上冲程时间（UT）、平均动脉压百分比（%MAP）、臂踝脉波速度（baPWV）、内皮素-1 （ET-1）水平低于BMS组（P0.05）。术后1年，DCB组通畅率高于BMS组(p结论：DCB治疗LEASO在改善血管功能、保护内皮功能方面优于BMS，达到1年通畅率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.