Memory-Enhancing Effects of Dauricine in Swiss Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies.

IF 3.3 4区医学 Q2 NEUROSCIENCES

NeuroMolecular Medicine Pub Date : 2025-06-05 DOI:10.1007/s12017-025-08839-z

Md Showkot Akbor, Md Sakib Al Hasan, Mst Farjanamul Haque, Zakir Husain, Md Tahajul Islam, Md Samim Hossen, Md Shadin, Shoyaeb Ahammed, Noshin Tasnim Yana, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam

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引用次数: 0

Abstract

The bisbenzylisoquinoline alkaloid dauricine (DAU) is known for its neuroprotective effects in animals. This study investigates the memory-enhancing effects of DAU in Swiss albino mice using both in vivo and in silico approaches, focusing on its interaction with the D2 dopamine (DOP) receptor. Behavioral tests, including marble burying, dust removal, and trained swimming, were used to assess cognitive performance, anxiety, and motor coordination. Molecular docking studies revealed that DAU binds strongly to the D2 DOP receptor (6CM4 protein), with a binding affinity of - 7.9 kcal/mol, forming significant hydrogen and hydrophobic bonds. Additionally, the pharmacokinetics and toxicity profiles of DAU were also evaluated. In vivo results showed that DAU improved behavioral performance in a dose-dependent manner, with the DAU-10 group showing significant (p < 0.05) enhancement compared to the control and standard groups. The DAU-10 + DOP-22 combination group also showed remarkable results compared to the standard alone. Pharmacokinetics and toxicity profiles were also assessed, revealing favorable properties but some concerns regarding mutagenicity and immunotoxicity. These findings suggest that DAU, especially when combined with D2 DOP receptor agonists, holds significant potential for memory enhancement and warrants further investigation.

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瑞士小鼠尿嘧啶的记忆增强作用：通过体内和计算机研究可能的分子干预。

bisbenzylisoquinoline生物碱dauricine （DAU）以其对动物的神经保护作用而闻名。本研究通过体内和计算机方法研究了DAU对瑞士白化病小鼠的记忆增强作用，重点研究了其与D2多巴胺（DOP）受体的相互作用。行为测试，包括埋大理石、除尘和训练游泳，用于评估认知表现、焦虑和运动协调。分子对接研究表明，DAU与D2 DOP受体（6CM4蛋白）结合较强，结合亲和力为- 7.9 kcal/mol，形成显著的氢键和疏水键。此外，还对DAU的药代动力学和毒性进行了评估。体内实验结果显示，DAU以剂量依赖的方式改善了行为表现，DAU-10组表现出显著的(p

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来源期刊

NeuroMolecular Medicine 医学-神经科学

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： NeuroMolecular Medicine publishes cutting-edge original research articles and critical reviews on the molecular and biochemical basis of neurological disorders. Studies range from genetic analyses of human populations to animal and cell culture models of neurological disorders. Emerging findings concerning the identification of genetic aberrancies and their pathogenic mechanisms at the molecular and cellular levels will be included. Also covered are experimental analyses of molecular cascades involved in the development and adult plasticity of the nervous system, in neurological dysfunction, and in neuronal degeneration and repair. NeuroMolecular Medicine encompasses basic research in the fields of molecular genetics, signal transduction, plasticity, and cell death. The information published in NEMM will provide a window into the future of molecular medicine for the nervous system.