Longitudinal patterns of loss of independence in Parkinson disease.

IF 2.3 Q3 CLINICAL NEUROLOGY

Neurodegenerative disease management Pub Date : 2025-06-04 DOI:10.1080/17582024.2025.2514982

Tsung-Ying Lee, Lisa M Shulman, Ann L Gruber-Baldini, Julia F Slejko, Mathangi Gopalakrishnan, Eberechukwu Onukwugha

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引用次数: 0

Abstract

Aim: To examine the longitudinal loss of independence (LOI) in Parkinson disease (PD) and introduce event visualization as a research tool.

Methods: Early-stage PD patients seen by a movement disorders specialist from 2003-2020 were included. LOI, defined as needing help with activities of daily living (ADLs), was assessed using the modified Older Americans Resources and Services Daily Function Questionnaire. EventFlow software visualized LOI patterns.

Results: The cohort included 296 patients (mean age 60.8; 61% male; 94% Hoehn & Yahr stages 1-2). At baseline, 91% were independent. LOI occurred in 133 patients for ≥ 1 ADL, and in 95 patients for ≥ 3 ADLs. Housework was the most frequent first ADL needing help (58 of 133), with a mean onset of 4.6 years. Among those with LOI, 57 (43%) regained independence at least once.

Conclusion: LOI in PD shows both transient and persistent patterns. Event visualization may aid understanding of progression and support patient counseling.

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帕金森病独立性丧失的纵向模式。

目的：探讨帕金森病（PD）的纵向独立性丧失（LOI），并引入事件可视化作为研究工具。方法：纳入2003-2020年由运动障碍专科医生就诊的早期PD患者。LOI被定义为需要日常生活活动（adl）的帮助，使用修改后的美国老年人资源和服务日常功能问卷进行评估。EventFlow软件可视化LOI模式。结果：纳入296例患者(平均年龄60.8岁；男性61%;94% Hoehn & Yahr阶段1-2)。在基线时，91%是独立的。≥1个ADL患者发生LOI 133例，≥3个ADL患者发生LOI 95例。家务劳动是最常见的首次需要帮助的ADL（133人中有58人），平均发病时间为4.6年。在LOI患者中，57例（43%）至少恢复了一次独立。结论：PD的LOI表现为短暂性和持续性。事件可视化可以帮助理解进展和支持患者咨询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurodegenerative disease management CLINICAL NEUROLOGY-

CiteScore

4.30

自引率

0.00%

发文量