Relationship between Serum Neurotransmitters and Cognitive Impairment in Adults with Obstructive Sleep Apnea.

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.2147/NSS.S522352

Fangli Yang, Simin Zhu, Xinru Lv, Yanuo Zhou, Zitong Wang, Chendi Lu, Zihan Xia, Haiqin Liu, Jin Hou, Jing Yan, Jingguo Chen, Hui Lv, Yewen Shi, Xiaoyong Ren

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Abstract

Introduction: The primary aim of this study was to investigate the serum levels of acetylcholine (Ach), norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) in two groups: those with obstructive sleep apnea (OSA) and cognitive impairment (CI) and those with OSA but no cognitive impairment (NCI).

Methods: A total of 30 adults (CI) and 75 adults (NCI) who completed polysomnography examinations between December 2023 and September 2024 were enrolled in the study. Enzyme-linked immunosorbent assays were used to measure serum levels of Ach, NE, DA, and 5-HT. Correlation and pooled analyses were conducted to assess the relationship between cognitive scores and four serological indicators. Logistic regression was performed to identify risk factors for cognitive impairment.

Results: Serum DA levels were higher in the CI group (275.10, 216.73-426.91, pg/mL) than in the NCI group (219.69, 138.46-261.97, pg/mL) (P < 0.001). No significant differences were found in serum NE, 5-HT, and Ach levels between the two groups (P = 0.582, P = 0.287, and P = 0.715, respectively). Moreover, the correlation analysis showed a correlation between DA and body mass index, Montreal Cognitive Assessment, average saturated oxygen (SaO₂), minimum SaO₂, the percentage of oxygen saturation less than 90% (all P < 0.05). The area under the receiver operating characteristic curve of DA was 0.732 (95% confidence interval: 0.628-0.836) (P < 0.001). Logistic regression analysis revealed a correlation between tonsil size, hypertension, DA, stuffy nose, and cognitive impairment.

Conclusion: Serum DA levels were associated with the severity of cognitive impairment in adults diagnosed with OSA and might serve as a potential, objective biomarker for identifying cognitive dysfunction in this population.

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成人阻塞性睡眠呼吸暂停患者血清神经递质与认知功能障碍的关系

本研究的主要目的是研究两组患者血清乙酰胆碱（Ach）、去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HT）水平：阻塞性睡眠呼吸暂停（OSA）伴认知功能障碍（CI）和OSA伴认知功能障碍（NCI）。方法：共有30名成人（CI）和75名成人（NCI）在2023年12月至2024年9月期间完成了多导睡眠图检查。采用酶联免疫吸附法测定血清乙酰胆碱、NE、DA和5-羟色胺水平。对认知评分与四项血清学指标之间的关系进行相关性分析和汇总分析。采用Logistic回归来确定认知障碍的危险因素。结果：CI组血清DA水平（275.10,216.73 ~ 426.91,pg/mL）高于NCI组（219.69,138.46 ~ 261.97,pg/mL）（P < 0.001）。两组血清NE、5-HT、Ach水平差异无统计学意义（P = 0.582、P = 0.287、P = 0.715）。相关分析显示，DA与体重指数、蒙特利尔认知评价、平均饱和氧（SaO2）、最小饱和氧（SaO2）、血氧饱和度小于90%相关（P < 0.05）。DA的受试者工作特征曲线下面积为0.732(95%可信区间为0.628 ~ 0.836)（P < 0.001）。Logistic回归分析显示扁桃体大小、高血压、DA、鼻塞和认知障碍之间存在相关性。结论：血清DA水平与诊断为OSA的成人认知功能障碍的严重程度相关，可能作为识别该人群认知功能障碍的潜在客观生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.