Epigenetic mechanisms of B cells: Recent advances in targeted therapies for SLE.

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, and abnormal B-cell function plays a key role in its pathogenesis. Multiple epigenetic mechanisms, such as DNA methylation, histone modification, and non-coding RNAs, can regulate B cell development, differentiation, and function. This review outlines the relationship between the epigenetic regulation of B cells and the pathogenesis of SLE and prospectively discusses possible therapeutic approaches.