The use of membrane-based therapeutic plasma exchange for the management of acute canine polyradiculoneuritis and reduction of antigen-specific IgG in one dog.

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2025-06-04 DOI:10.1111/jsap.13885

Z P Greenfield, N M Etedali, D M Cimino, S K Halstead, H J Willison

引用次数: 0

Abstract

Acute canine polyradiculoneuritis is one of the most common lower motor neuron diseases in dogs. Given similarities to Guillain-Barré syndrome in people, an immune-mediated component has long been suspected. In veterinary medicine, two studies have documented specific antibodies as serum biomarkers for acute canine polyradiculoneuritis, including anti-GM2 and anti-GalNAc-GD1a immunoglobulin G anti-glycolipid antibodies. This case report documents the first use of membrane-based therapeutic plasma exchange for the management of acute canine polyradiculoneuritis as well as an overall reduction in anti-GM2 IgG and anti-GalNAc-GD1a IgG with subsequent treatments. The clinical recovery in this dog was rapid, with improved motor function within 48 hours of her first treatment and a complete return to normal within 1 month.

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应用膜基治疗血浆置换治疗急性犬多根神经炎并降低1只犬的抗原特异性IgG。

急性犬多根神经炎是犬最常见的下运动神经元疾病之一。鉴于与人类格林-巴勒综合征的相似性，长期以来人们一直怀疑免疫介导的成分。在兽医学领域，有两项研究证实了特异性抗体作为急性犬多根神经炎的血清生物标志物，包括抗gm2和抗galnac - gd1a免疫球蛋白G抗糖脂抗体。本病例报告记录了首次使用基于膜的治疗性血浆置换治疗急性犬多根神经炎，以及在随后的治疗中抗gm2 IgG和抗galnac - gd1a IgG的总体降低。这只狗的临床恢复很快，在第一次治疗后48小时内运动功能得到改善，1个月内完全恢复正常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association