Clinical spectrum of AES (Acute encephalitis syndrome) and a syndromic approach for its diagnosis.

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-06-05 DOI:10.1007/s13365-025-01261-y
Sidharth S, Sarada Devi K L, Sreelatha K H
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引用次数: 0

Abstract

Acute encephalitis syndrome (AES) is now being used for surveillance in all encephalitis endemic zones irrespective of the etiology. Numerous viral pathogens possess the ability to invade the CNS and produce neurologic dysfunction. We performed a hospital-based descriptive study between January 2019 to January 2020 in the Department of Microbiology, GMC, Thiruvananthapuram taking samples from 193 AES patients admitted under the Departments of Internal Medicine, Neurology & Paediatrics. The samples were proceeded with PCR/ELISA depending on the clinical history. A viral etiology was established in 48 cases (24.9%) & most were caused by EBV (5.7%). MRI revealed temporal lobe involvement in 9 patients. 20% cases had post-encephalitic sequelae-focal neurological deficits and persistent seizures. Most number of patients were found to have infected with Epstein- Barr virus. Identification of the causative agent is of great importance in AES, as rapid detection and confirmation of etiological agent will have a tremendous impact on the management of outbreaks as well as patient's disease.

AES(急性脑炎综合征)的临床谱及其综合征诊断方法。
急性脑炎综合征(AES)目前被用于监测所有脑炎流行区,无论其病因如何。许多病毒病原体具有侵入中枢神经系统并产生神经功能障碍的能力。我们在2019年1月至2020年1月期间在蒂鲁凡得琅邦GMC微生物科进行了一项基于医院的描述性研究,从内科、神经内科和儿科住院的193例AES患者中采集了样本。根据临床病史进行PCR/ELISA检测。48例(24.9%)为病毒病原,多数为EBV(5.7%)。MRI显示9例患者颞叶受累。20%的病例有脑后后遗症-局灶性神经功能缺损和持续癫痫发作。大多数患者被发现感染了爱泼斯坦-巴尔病毒。病原的鉴定在AES中非常重要,因为病原的快速发现和确认将对疫情和患者疾病的管理产生巨大影响。
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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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