JAG2 AS A KEY MEDIATOR IN PORPHYROMONAS GINGIVALIS-INDUCED PERIODONTAL INFLAMMATION.

Abstract

Porphyromonas gingivalis (P. gingivalis) is a key pathogen in chronic periodontitis, but its exact pathogenic mechanisms remain unclear. This study aimed to investigate the transcriptomic changes induced by P. gingivalis and identify potential key pathways involved in periodontal pathogenesis. We performed high-throughput sequencing and bioinformatic analyses on oral epithelial cell exposed to P. gingivalis. Differential gene expression analysis revealed 106 significantly altered genes (p<0.05, |log2FC|>1). KEGG pathway enrichment analysis highlighted the involvement of TNF signaling, Notch signaling, and ribosomal pathways. Protein-protein interaction network analysis identified JAG2, a Notch ligand, as a key hub gene significantly downregulated in P. gingivalis-treated samples. Our findings provide new insights into the molecular mechanisms of P. gingivalis-induced periodontal inflammation and suggest potential therapeutic targets, particularly within the Notch and IL-6 signaling pathways, for the treatment of periodontitis.