STUDY OF THE MORBIDITY RATES OF ENDOMETRIAL HYPERPLASIA IN THE REPUBLIC OF KAZAKHSTAN FOR THE PERIOD 2012-2022.

Abstract

Relevance: Endometrial hyperplasia (EH) is a gynecological disease characterized by pathological overgrowth of the endometrium as a result of the unhindered action of estrogens. The relevance of studying this disease is based on the morbidity rate of this disease in women in the Republic of Kazakhstan, which, in the absence of timely diagnosis, treatment and dynamic monitoring, may lead to the rapid progression to endometrial cancer (EC).

Aim of the study: To analyze the morbidity rates of EH and its histological types in the Republic of Kazakhstan for the period 2012-2022.

Materials and methods: A descriptive, retrospective epidemiological analysis of the morbidity of EH and its main histological types among the female population of the Republic of Kazakhstan for the period from January 1, 2012, to December 31, 2022, was carried out. The study used data from the Information System "Electronic Register of Inpatient Patients" for newly identified cases with histologically confirmed diagnoses according to the International Statistical Classification of Diseases and Related Health Problems, 10 WHO revision, N85.0 - Glandular endometrial hyperplasia (non-atypical endometrial hyperplasia), N85.1 - Adenomatous endometrial hyperplasia (atypical hyperplasia endometrium). Epidemiological indicators were calculated per 100,000 female population. The database formation and statistical processing of the results were carried out using Microsoft Excel and the statistical package of the SPSS Statistics 27 program.

Results: The analysis showed an increase in the morbidity of EH and its main histological types in the Republic of Kazakhstan over the period 2012-2022. It was noted that with the alignment of the dynamic range indicators, the morbidity of EH increased by an average of 13.7% annually. During the analyzed period, the average annual morbidity of EH was 4.59±0.81 cases per 100,000 female population (95% CI=2.77-6.40), atypical EН - 4.32±0.78 (95% CI=2.61-6.04), atypical GE - 0.26±0.59 (95% CI=0.13-0.39), respectively. The main trends of changes in the morbidity of EH in the context of regions have been identified. It was found that the peak morbidity of EH and its main histological types occurred in the age group of 45-49 years.

Conclusion: The identified trends in the morbidity of EH and its histological types in the population of the Republic of Kazakhstan have shown the need for a more detailed study of risk factors contributing to the development of EH and the improvement of healthcare services.