Normative isokinetic knee strength values and prediction models in non-athletic Chinese adults.

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-05-21 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1573267
Kun Liu, Lulu Yin, Ye Zhang, Gongliang Liu, Ping Fang, Yanhong Ma, Lihua Huang
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引用次数: 0

Abstract

Background: Establishing normative isokinetic muscle strength values and prediction models for knee joints in non-athletic healthy Chinese adults aids in clinical assessments, diagnosis, and rehabilitation. However, there has been limited research on these normal reference values, particularly involving large sample cohorts. Therefore, this study aimed to develop normative reference values and predictive models for knee joint isokinetic muscle strength across different age groups and genders in non-athletic healthy Chinese adults.

Methods: A total of 2,208 participants aged between 20-70 years old were included in the study. The participants were divided into two groups by gender and further divided into five age groups: 20-29, 30-39, 40-49, 50-59 and 60-69 years old, resulting in a total of 10 groups. Key parameters, including peak torque of knee flexors and extensors, relative peak torque, peak torque ratio of flexors to extensors, peak torque angle and work, were collected using an isokinetic dynamometer at angular velocities of 60°/s and 180°/s. Two-way analysis of variance was utilised to analyse the characteristics and differences of these parameters amongst different age groups and genders. Pearson correlation coefficients were calculated to examine the relationships between these parameters and gender, age, height, weight and body mass index. Predictive models were developed using linear regression and various machine learning techniques.

Results: Males exhibited significantly higher knee isokinetic strength values than females across all age groups, with knee extensor strength 20.47%-38.01% higher and knee flexor strength 22.91%-43.42% higher at both 60°/s and 180°/s. Muscle strength showed a moderate negative correlation with age, indicating a decline with increasing age. Extension strength values were greater than flexion, and measurements at 180°/s were lower compared to 60°/s. The multilayer perceptron regressor demonstrated the highest predictive capability among the models tested.

Conclusion: This study provides comprehensive normative reference values and predictive models for knee joint isokinetic muscle strength in non-athletic healthy Chinese adults. The results highlight significant gender and age differences, offering valuable data for clinical assessments and personalized rehabilitation strategies to improve knee joint health and overall quality of life.

中国非运动成人的规范等速膝关节力量值及预测模型。
背景:建立非运动健康中国成人膝关节的规范等速肌力值和预测模型有助于临床评估、诊断和康复。然而,对这些正常参考值的研究有限,特别是涉及大样本队列的研究。因此,本研究旨在建立不同年龄和性别的中国非运动健康成人膝关节等速肌力的规范性参考值和预测模型。方法:共纳入2208名年龄在20-70岁之间的参与者。参与者按性别分为两组,再分为20-29岁、30-39岁、40-49岁、50-59岁和60-69岁五个年龄段,共10组。在角速度为60°/s和180°/s时,采用等速测功机采集膝关节屈伸肌峰值扭矩、相对峰值扭矩、屈伸肌峰值扭矩比、峰值扭矩角和功等关键参数。采用双向方差分析分析这些参数在不同年龄组和性别之间的特征和差异。计算Pearson相关系数来检验这些参数与性别、年龄、身高、体重和身体质量指数之间的关系。使用线性回归和各种机器学习技术开发了预测模型。结果:在所有年龄组中,男性的膝关节等速力量值都明显高于女性,在60°/s和180°/s时,膝关节伸肌力量高20.47%-38.01%,膝关节屈肌力量高22.91%-43.42%。肌肉力量与年龄呈中等负相关,随着年龄的增长而下降。拉伸强度值大于弯曲强度值,180°/s下的测量值低于60°/s。多层感知器回归器在测试的模型中显示出最高的预测能力。结论:本研究为中国非运动健康成人膝关节等速肌力提供了全面的规范性参考价值和预测模型。结果突出了显著的性别和年龄差异,为临床评估和个性化康复策略提供了有价值的数据,以改善膝关节健康和整体生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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