Kun Liu, Lulu Yin, Ye Zhang, Gongliang Liu, Ping Fang, Yanhong Ma, Lihua Huang
{"title":"Normative isokinetic knee strength values and prediction models in non-athletic Chinese adults.","authors":"Kun Liu, Lulu Yin, Ye Zhang, Gongliang Liu, Ping Fang, Yanhong Ma, Lihua Huang","doi":"10.3389/fbioe.2025.1573267","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Establishing normative isokinetic muscle strength values and prediction models for knee joints in non-athletic healthy Chinese adults aids in clinical assessments, diagnosis, and rehabilitation. However, there has been limited research on these normal reference values, particularly involving large sample cohorts. Therefore, this study aimed to develop normative reference values and predictive models for knee joint isokinetic muscle strength across different age groups and genders in non-athletic healthy Chinese adults.</p><p><strong>Methods: </strong>A total of 2,208 participants aged between 20-70 years old were included in the study. The participants were divided into two groups by gender and further divided into five age groups: 20-29, 30-39, 40-49, 50-59 and 60-69 years old, resulting in a total of 10 groups. Key parameters, including peak torque of knee flexors and extensors, relative peak torque, peak torque ratio of flexors to extensors, peak torque angle and work, were collected using an isokinetic dynamometer at angular velocities of 60°/s and 180°/s. Two-way analysis of variance was utilised to analyse the characteristics and differences of these parameters amongst different age groups and genders. Pearson correlation coefficients were calculated to examine the relationships between these parameters and gender, age, height, weight and body mass index. Predictive models were developed using linear regression and various machine learning techniques.</p><p><strong>Results: </strong>Males exhibited significantly higher knee isokinetic strength values than females across all age groups, with knee extensor strength 20.47%-38.01% higher and knee flexor strength 22.91%-43.42% higher at both 60°/s and 180°/s. Muscle strength showed a moderate negative correlation with age, indicating a decline with increasing age. Extension strength values were greater than flexion, and measurements at 180°/s were lower compared to 60°/s. The multilayer perceptron regressor demonstrated the highest predictive capability among the models tested.</p><p><strong>Conclusion: </strong>This study provides comprehensive normative reference values and predictive models for knee joint isokinetic muscle strength in non-athletic healthy Chinese adults. The results highlight significant gender and age differences, offering valuable data for clinical assessments and personalized rehabilitation strategies to improve knee joint health and overall quality of life.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1573267"},"PeriodicalIF":4.3000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133959/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1573267","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Establishing normative isokinetic muscle strength values and prediction models for knee joints in non-athletic healthy Chinese adults aids in clinical assessments, diagnosis, and rehabilitation. However, there has been limited research on these normal reference values, particularly involving large sample cohorts. Therefore, this study aimed to develop normative reference values and predictive models for knee joint isokinetic muscle strength across different age groups and genders in non-athletic healthy Chinese adults.
Methods: A total of 2,208 participants aged between 20-70 years old were included in the study. The participants were divided into two groups by gender and further divided into five age groups: 20-29, 30-39, 40-49, 50-59 and 60-69 years old, resulting in a total of 10 groups. Key parameters, including peak torque of knee flexors and extensors, relative peak torque, peak torque ratio of flexors to extensors, peak torque angle and work, were collected using an isokinetic dynamometer at angular velocities of 60°/s and 180°/s. Two-way analysis of variance was utilised to analyse the characteristics and differences of these parameters amongst different age groups and genders. Pearson correlation coefficients were calculated to examine the relationships between these parameters and gender, age, height, weight and body mass index. Predictive models were developed using linear regression and various machine learning techniques.
Results: Males exhibited significantly higher knee isokinetic strength values than females across all age groups, with knee extensor strength 20.47%-38.01% higher and knee flexor strength 22.91%-43.42% higher at both 60°/s and 180°/s. Muscle strength showed a moderate negative correlation with age, indicating a decline with increasing age. Extension strength values were greater than flexion, and measurements at 180°/s were lower compared to 60°/s. The multilayer perceptron regressor demonstrated the highest predictive capability among the models tested.
Conclusion: This study provides comprehensive normative reference values and predictive models for knee joint isokinetic muscle strength in non-athletic healthy Chinese adults. The results highlight significant gender and age differences, offering valuable data for clinical assessments and personalized rehabilitation strategies to improve knee joint health and overall quality of life.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.