Electrocardiogram abnormalities and CVD mortality: prospective cohort study of Tehran lipid and glucose study.

IF 3.6 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

BMC Public Health Pub Date : 2025-06-04 DOI:10.1186/s12889-025-23254-6

Soma Mahmoodian, Davood Khalili, Fereidoun Azizi, Noushin Haddizadeh, Bijan Nouri, Abbas Aghaei

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引用次数: 0

Abstract

Background: The incorporation of electrocardiogram (ECG) abnormalities with other clinical indicators can strengthen the hypothesis regarding the improvement of diagnosis and the enhancement of screening accuracy for cardiovascular diseases. This study aimed to determine the risk of mortality from cardiovascular diseases (CVD) based on ECG abnormalities, in addition to other known risk factors, within the Tehran Lipid and Glucose Study (TLGS).

Methods: In this prospective cohort study conducted within the framework of the TLGS, 6,422 individuals aged 30 and older, who had ECG data and no history of cardiovascular disease, were examined over a follow-up period with a median of 18.1 years (IQR: 1.05). Logistic regression models, adjusted for age, gender, abdominal obesity, BMI, high blood pressure, LDL cholesterol levels, fasting blood glucose, smoking status, and education level, were used to estimate the odds ratios (OR) for ECG abnormalities regarding CVD mortality.

Results: Overall, during the 19-year follow-up period, 233 CVD-related deaths occurred, resulting in a cumulative incidence of mortality of 3.63% in the study population. Individuals with Q-wave abnormalities (OR = 2.060, 95% CI: 1.327-3.198, P = 0.001) and T-wave abnormalities (OR = 1.990, 95% CI: 1.327-3.986, P = 0.001) had approximately twice the risk of CVD mortality compared to those without these abnormalities. However, ECG abnormalities such as ST-segment (OR = 1.169, 95% CI: 0.728-1.879, P = 0.518), QRS duration (OR = 0.780, 95% CI: 0.385-1.582, P = 0.492), and PR interval (OR = 1.406, 95% CI: 0.297-6.662, P = 0.668) did not show a significant association with CVD mortality.

Conclusion: Among the ECG abnormalities (ST, T, Q, PR, QRS), Q and T abnormalities are associated with CVD mortality. It can be concluded that ECG abnormalities in asymptomatic adults are related to the risk of CVD mortality and can serve as warning factors for the development of mortality from CVD.

查看原文本刊更多论文

心电图异常和心血管疾病死亡率：德黑兰血脂和血糖研究的前瞻性队列研究。

背景：心电图异常与其他临床指标的结合可以加强对心血管疾病的诊断和筛查准确性的假设。本研究旨在确定德黑兰脂质和葡萄糖研究（TLGS）中基于ECG异常以及其他已知危险因素的心血管疾病（CVD）死亡风险。方法：在TLGS框架内进行的这项前瞻性队列研究中，6,422名年龄在30岁及以上、有心电图数据且无心血管疾病史的个体接受了随访，随访时间中位数为18.1年（IQR: 1.05）。采用Logistic回归模型，校正年龄、性别、腹部肥胖、BMI、高血压、低密度脂蛋白胆固醇水平、空腹血糖、吸烟状况和教育水平，估计与心血管疾病死亡率相关的ECG异常的优势比（OR）。结果：总体而言，在19年的随访期间，发生了233例cvd相关死亡，导致研究人群的累积死亡率为3.63%。q波异常（OR = 2.060, 95% CI: 1.327-3.198, P = 0.001）和t波异常（OR = 1.990, 95% CI: 1.327-3.986, P = 0.001）的个体与没有这些异常的个体相比，心血管疾病死亡的风险约为两倍。然而，心电图异常，如st段（OR = 1.169, 95% CI: 0.728-1.879, P = 0.518）、QRS持续时间（OR = 0.780, 95% CI: 0.385-1.582, P = 0.492）和PR间隔（OR = 1.406, 95% CI: 0.297-6.662, P = 0.668）与CVD死亡率无显著相关性。结论：在心电图异常（ST、T、Q、PR、QRS）中，Q、T异常与CVD死亡率相关。由此可见，无症状成人心电图异常与CVD死亡风险相关，可作为CVD死亡发展的预警因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.