Associations of depressive symptoms and lifestyles with cognitive function: results from two cross-sectional studies among middle-age and older Chinese populations

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-06-03 DOI:10.1016/j.jad.2025.119573

Shengli Chen , Wencai Ke , Xin Guan , Shiru Hong , Sheng Wu , Zirong Yu , Jie Lin , Chenming Wang , Ming Fu , Yang Xiao , Yuhan Zhou , Chenliang Liu , Guorong Zhong , Yingqian You , Yuxi Wang , Hui Zhao , Yichi Zhang , Yansen Bai , Zhengce Wan , Yong Lin , Huan Guo

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引用次数: 0

Abstract

Background

Depression and cognitive decline are both major health problems worldwide. This study aims to investigate the effects of depressive symptoms and its joint function with lifestyles on cognitive function among the Chinese populations.

Methods

This research included two cross-sectional studies from Hubei (n = 7756) and Shanghai (n = 4751), China. The depressive symptoms were surveyed by the 15-item Geriatric Depression Scale (GDS-15), and cognitive function was assessed by the Mini-mental State Examination (MMSE).

Results

We observed significant association between depression and decreased MMSE score [β (95%CI) = −0.70 (−0.97, −0.42) and −3.15 (−3.59, −2.70) in Hubei and Shanghai, respectively] and elevated risk of MCI [OR (95%CI) = 1.59 (1.20, 2.08) and 2.75 (2.06, 3.66), respectively] in both populations. Additionally, individuals who reported physically active, kept an optimal sleep duration, and higher healthy lifestyle score (HLS) exhibited a better cognition in both populations. More importantly, the adverse associations between depressive symptoms and cognition were diminished among subjects adopting five types of healthy lifestyles (HLS = 5) [Hubei: β (95%CI) = −0.20 (−0.82, 0.41) and OR (95%CI) =0.82 (0.24, 2.12), P-int = 0.047 and 0.046; Shanghai: β (95%CI) = −0.80 (−1.70, 0.10) and OR (95%CI) =1.85 (0.53, 5.06), P-int < 0.001 and 0.151]. Furthermore, we observed joint effects of non-depressed status with healthy lifestyles on cognition.

Conclusion

Depressive symptoms are associated with impaired cognitive function and this association could be attenuated by healthy lifestyles.

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抑郁症状和生活方式与认知功能的关系：来自中国中老年人群的两项横断面研究的结果

抑郁症和认知能力下降都是世界范围内的主要健康问题。本研究旨在探讨中国人群抑郁症状及其与生活方式的联合功能对认知功能的影响。方法本研究包括来自中国湖北（n = 7756）和上海（n = 4751）的两项横断面研究。采用15项老年抑郁量表（GDS-15）调查抑郁症状，采用简易精神状态检查（MMSE）评估认知功能。结果我们发现，在湖北和上海，抑郁与MMSE评分降低[β (95%CI)分别为- 0.70（- 0.97,- 0.42）和- 3.15(- 3.59,- 2.70)]和MCI风险升高[OR （95%CI）分别为1.59（1.20,2.08）和2.75(2.06,3.66)]存在显著相关性。此外，报告体力活动、保持最佳睡眠时间和较高健康生活方式评分（HLS）的个体在这两个人群中表现出更好的认知能力。更重要的是，在采用五种健康生活方式的受试者中，抑郁症状与认知之间的不良关联减弱（HLS = 5）[湖北：β (95%CI) = - 0.20 (- 0.82, 0.41), OR (95%CI) =0.82 (0.24, 2.12), P-int = 0.047和0.046；上海:β(95% ci) =−0.80(−1.70、0.10)和1.85(95%可信区间)= (0.53,5.06),P-int & lt;0.001和0.151]。此外，我们观察到非抑郁状态与健康生活方式对认知的共同影响。结论抑郁症状与认知功能障碍相关，健康的生活方式可减轻抑郁症状与认知功能障碍的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.