A comprehensive review of high-performance photoacoustic microscopy systems

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2025-06-04 DOI:10.1016/j.pacs.2025.100739

Eunwoo Park , Donggyu Kim , Mingyu Ha , Donghyun Kim , Chulhong Kim

引用次数: 0

Abstract

Photoacoustic microscopy (PAM), an imaging modality with emerging importance in diverse biomedical applications, provides excellent structural and functional information at the micro-scale. Technological innovations have significantly enhanced PAM’s performance, including sensitivity and contrast, making it a powerful tool. This review explores high-performance PAM, focusing on its signal-to-noise ratio, imaging speed, resolution, depth, functionality, and practicality, and commenting on the role of artificial intelligence in enhancing each feature. After providing comprehensive insights, the review concludes with future directions for developing high-performance PAM for advanced biomedical imaging and clinical applications.

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高性能光声显微镜系统的综合综述

光声显微镜（PAM）是一种在多种生物医学应用中日益重要的成像方式，它提供了微观尺度上优秀的结构和功能信息。技术革新大大提高了PAM的性能，包括灵敏度和对比度，使其成为一个强大的工具。本文探讨了高性能PAM，重点关注其信噪比、成像速度、分辨率、深度、功能和实用性，并评论了人工智能在增强这些特性中的作用。最后，展望了高性能PAM在先进生物医学成像和临床应用方面的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.