Exercise types for efficacy and adherence in adolescents and young adults with depression: A systematic review with network meta-analysis

IF 2.3 3区医学 Q2 PSYCHIATRY

Mental Health and Physical Activity Pub Date : 2025-06-02 DOI:10.1016/j.mhpa.2025.100696

Ting Fan, Geng Li, Chengzhen Liu

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引用次数: 0

Abstract

Background

While existing research shows that exercise can positively influence depression, it remains uncertain whether the efficacy and adherence of different exercise types on depressed adolescents and young adults differ.

Aims

This study performed a network meta-analysis of randomized controlled trials (RCTs) to determine the relative efficacy and adherence of exercise types in adolescents and young adults with depression.

Methods

A comprehensive search was conducted in PubMed, The Cochrane Library, PsycINFO, Web of Science, Scopus, CNKI, and Wanfang, with the initial search covering studies up to October 2023 and an updated search performed in April 2025 to ensure inclusion of the most recent evidence. Studies comparing the efficacy and adherence of aerobic exercise, resistance exercise, mind-body exercise, or mixed exercise to usual care in adolescents and young adults with depression were included. Network meta-analysis with frequentist approaches was used for analysis in Stata 16.0.

Results

We included 48 randomized controlled trials comprising 3872 participants. Aerobic, resistance, mind-body, and mixed exercise interventions all demonstrated significant efficacy in alleviating depressive symptoms (p < 0.05), with adherence rates comparable to those observed in usual care (p > 0.05). Notably, resistance exercise emerged as the most effective approach, ranking highest in both reducing depression (SUCRA = 81.3) and sustaining adherence (SUCRA = 73.29). Additionally, intervention efficacy was significantly moderated by both the duration of the intervention and the average age of participants.

Conclusion

These findings highlight the superiority of resistance exercise in treating depression among adolescents and young adults. Moreover, intervention duration and mean participant age were identified as key factors influencing treatment efficacy. Together, these results offer valuable evidence to inform clinical decision-making and enhance current guidelines for managing depression in this vulnerable population.

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运动类型对青少年和青年抑郁症患者疗效和依从性的影响：网络荟萃分析的系统综述

虽然现有研究表明运动对抑郁症有积极影响，但不同运动类型对抑郁症青少年和年轻人的疗效和依从性是否存在差异仍不确定。目的：本研究对随机对照试验（RCTs）进行了网络荟萃分析，以确定运动类型对青少年和青年抑郁症患者的相对疗效和依从性。方法在PubMed、Cochrane Library、PsycINFO、Web of Science、Scopus、CNKI、万方等网站进行综合检索，初步检索涵盖截至2023年10月的研究，并于2025年4月进行更新检索，以确保纳入最新证据。研究比较了有氧运动、抗阻运动、身心运动或混合运动与常规护理对青少年和年轻抑郁症患者的疗效和依从性。在Stata 16.0中使用网络元分析和频率分析方法进行分析。结果纳入48项随机对照试验，共3872名受试者。有氧运动、抵抗运动、身心运动和混合运动干预均显示出显著的缓解抑郁症状的疗效(p <；0.05)，依从率与常规护理中观察到的依从率相当(p >；0.05)。值得注意的是，阻力运动是最有效的方法，在减少抑郁（SUCRA = 81.3）和保持坚持（SUCRA = 73.29）方面排名最高。此外，干预效果被干预的持续时间和参与者的平均年龄显著调节。结论抗阻运动在治疗青少年抑郁症中的优势。此外，干预时间和参与者平均年龄是影响治疗效果的关键因素。总之，这些结果为临床决策提供了有价值的证据，并加强了目前在这一弱势群体中管理抑郁症的指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mental Health and Physical Activity PSYCHIATRY-

CiteScore

6.70

自引率

6.40%

发文量

审稿时长

32 days

期刊介绍： The aims of Mental Health and Physical Activity will be: (1) to foster the inter-disciplinary development and understanding of the mental health and physical activity field; (2) to develop research designs and methods to advance our understanding; (3) to promote the publication of high quality research on the effects of physical activity (interventions and a single session) on a wide range of dimensions of mental health and psychological well-being (eg, depression, anxiety and stress responses, mood, cognitive functioning and neurological disorders, such as dementia, self-esteem and related constructs, psychological aspects of quality of life among people with physical and mental illness, sleep, addictive disorders, eating disorders), from both efficacy and effectiveness trials;