Cerebral amyloid angiopathy in patients with Dementia with Lewy Bodies: A clinical and hippocampal morphology study

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-05-26 DOI:10.1016/j.parkreldis.2025.107892

Caroline Hall , Paolo Salvioni Chiabotti , Giulia Bommarito , Yasser Alemán-Goméz , Sabrina Carlier , Mirco Nasuti , Daniel Damian , Mario Jreige , Vincent Dunet , Olivier Rouaud , Patric Hagmann , Olaf Blanke , Alessandra Griffa , Gilles Allali

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引用次数: 0

Abstract

Introduction

Dementia with Lewy Bodies (DLB) is often associated with Cerebral Amyloid Angiopathy (CAA) based on pathological studies. Current literature in DLB reveals heterogenous findings regarding CAA effects on cognition, but overall suggests a diffuse impact on different cognitive domains, depending in parts on CAA severity. Reduced hippocampal volumes have also been reported in CAA patients. This study aims first at reporting the prevalence of CAA in DLB according to the Boston Criteria 2.0, and second at analyzing the impact of CAA on neuropsychological performances and hippocampal volumes in DLB patients.

Method

We retrospectively evaluated the prevalence of CAA in DLB patients followed at the Leenaards Memory Center (Lausanne University Hospital, Lausanne, Switzerland) with the Boston Criteria version 2.0 and compared cognitive performance and hippocampal volumes between DLB+CAA and DLB-CAA patients.

Results

87 DLB patients (77.5 ± 7.2yo; 34.5 % females) were included. We found that 65.5 % of DLB patients presented with any (probable + possible) CAA. Cognitive performances and hippocampal volumes (total and segmentation) were similar between both groups.

Conclusion

This study shows that the presence of CAA does not impact cognition and hippocampal volume in patients with DLB.

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路易体痴呆患者的脑淀粉样血管病：临床和海马形态学研究

基于病理研究，路易体痴呆（DLB）常与脑淀粉样血管病（CAA）相关。目前关于DLB的文献揭示了CAA对认知影响的异质性发现，但总体上表明，CAA对不同认知领域的影响是分散的，这部分取决于CAA的严重程度。CAA患者也有海马体积减小的报道。本研究首先根据波士顿标准2.0报告CAA在DLB中的患病率，其次分析CAA对DLB患者神经心理表现和海马体积的影响。方法回顾性评估Leenaards记忆中心（Lausanne University Hospital, Lausanne, Switzerland）随访的DLB患者中CAA的患病率，采用波士顿标准2.0版，比较DLB+CAA和DLB-CAA患者的认知表现和海马体积。结果87例DLB患者(77.5±7.2岁；34.5%为女性)。我们发现65.5%的DLB患者出现任何（可能的+可能的）CAA。两组之间的认知表现和海马体积（总和分割）相似。结论本研究显示CAA的存在不影响DLB患者的认知和海马体积。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.