Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2025-02-14 DOI:10.1002/cdt3.70000

Jingshuang Yan, Rongrong Ren, Ruqi Chang, Wanyue Dan, Xiaohan Zhang, Fei Pan, Bin Yan, Hongzhe Lee, Ni Josie, Gang Sun, Lihua Peng, Gary D. Wu, Yunsheng Yang

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引用次数: 0

Abstract

Background

The increasing incidence of inflammatory bowel disease (IBD) presents significant medical and societal challenges. A well-designed IBD database is crucial for both epidemiological studies and clinical management. However, inconsistencies between regional databases hinder cross-institutional and international research, especially between Eastern and Western societies.

Methods

We developed a new IBD database, the 301 IBD database, integrating the IBD clinical characteristics from the Penn IBD database (USA) and the latest IBD guidelines and consensus and clinical practices of the Chinese PLA General Hospital (PLAGH). We applied this database to analyze clinical data of IBD inpatients at PLAGH from 2008 to 2023.

Results

The 301 IBD database contains 490 items in 6 sections including demographic characteristics, personal history, clinical phenotype, disease activity, laboratory tests and examinations, and treatment. Features of the 301 IBD database include inpatient focus, biochemical indicators and opportunistic infection focus, and more about ulcerative colitis (UC)-associated complications. Single-center analysis revealed an increasing hospitalization trend, from 2.35% in 2008 to 3.94% in 2023. We found that the clinical characteristics of our UC inpatients are predominantly male (62.5%), extensive lesions (55.1%), low usage of biologics (4.1%), and a high incidence of UC-CRC (3.0%). The clinical characteristics of CD inpatients included male predominance (68.39%), early onset age (35.43 ± 14.75-year-old), and high rate of surgery (25.81%).

Conclusion

The 301 IBD database, integrating Eastern and Western clinical data, provides a valuable tool for IBD clinical research. Future international, multicenter collaborations are expected to further enhance its utility.

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整合东西方临床特征的新型炎症性肠病临床数据库的开发和初步应用

背景：炎症性肠病（IBD）发病率的上升给医学和社会带来了重大挑战。一个设计良好的IBD数据库对于流行病学研究和临床管理都至关重要。然而，区域数据库之间的不一致性阻碍了跨机构和国际研究，特别是东西方社会之间的研究。方法将美国Penn IBD数据库的IBD临床特征与中国人民解放军总医院（PLAGH）最新IBD指南、共识和临床实践相结合，建立新的IBD数据库301 IBD数据库。我们应用该数据库分析2008 - 2023年PLAGH IBD住院患者的临床资料。结果301 IBD数据库包含人口统计学特征、个人病史、临床表型、疾病活动性、实验室检查和治疗6个部分490项。301 IBD数据库的特征包括住院焦点、生化指标和机会性感染焦点，以及更多关于溃疡性结肠炎（UC）相关并发症的信息。单中心分析显示住院率呈上升趋势，从2008年的2.35%上升到2023年的3.94%。我们发现UC住院患者的临床特征主要是男性（62.5%），病变广泛（55.1%），生物制剂使用率低（4.1%），UC- crc发病率高（3.0%）。CD住院患者的临床特点为男性居多（68.39%）、发病年龄早（35.43±14.75岁）、手术率高（25.81%）。结论301 IBD数据库整合了东西方临床资料，为IBD临床研究提供了有价值的工具。未来的国际、多中心合作有望进一步提高其效用。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.