Microalbuminuria Is Associated With Left Ventricular Systolic Function in Newly Diagnosed Hypertensive Patients

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2025-06-06 DOI:10.1111/echo.70216

Selim Aydemir, Sidar Şiyar Aydın, Onur Altınkaya, Murat Özmen, Emrah Aksakal, İbrahim Halil Tanboğa

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引用次数: 0

Abstract

Purpose

Hypertension (HT) is a significant disease and cardiovascular (CV) risk factor worldwide. In patients with HT, cardiac dysfunction constitutes the main problem. Urinary albumin creatinine ratio (UACR), a practical measurement for diagnosing microalbuminuria, is associated with adverse CV events in HT patients. Our study aimed to examine the relationships between UACR and cardiac functions in newly diagnosed HT patients.

Methods

Our study was designed prospectively. Patients diagnosed with HT were started on angiotensin-converting enzyme inhibitors (ACEIs) as treatment and were called for a follow-up after 3 months. Before and after treatment, spot urine samples, 24-h blood pressure monitoring, Conventional transthoracic echocardiography (TTE) parameters, and left ventricular global longitudinal strain (LVGLS) were calculated by Speckle-tracking echocardiography. A linear regression model evaluated the relationship between UACR and cardiac parameters measured on TTE.

Results

Our study consists of 104 patients diagnosed with HT. The mean age of the patients was 49.1 ± 9.5 years, and 44.2% were male. With treatment, mean, night, and day systolic blood pressure (SBP), pulse pressure, and arterial pressure decreased, and these decreases were significantly associated with UACR. Additionally, microalbuminuria decreased with treatment, and an independent and significant association was observed between the decrease in UACR and the improvement in LVGLS in linear regression analysis.

Conclusion

In our study, a significant relationship was observed between microalbuminuria and LVGLS. It was observed that treatments that reduce microalbuminuria and blood pressure control in HT patients were associated with improvement in LV functions, and UACR, which shows microalbuminuria, may be useful in monitoring the improvement in LV systolic functions.

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新诊断高血压患者微量白蛋白尿与左心室收缩功能相关

目的高血压（HT）是世界范围内重要的心血管疾病和危险因素。在HT患者中，心功能障碍是主要问题。尿白蛋白肌酐比（UACR）是一种诊断微量白蛋白尿的实用测量方法，与HT患者的不良CV事件相关。本研究旨在探讨新诊断HT患者UACR与心功能的关系。方法采用前瞻性设计。诊断为HT的患者开始使用血管紧张素转换酶抑制剂（ACEIs）作为治疗，并在3个月后进行随访。采用斑点跟踪超声心动图计算治疗前后尿样、24 h血压监测、常规经胸超声心动图（TTE）参数、左心室总纵应变（LVGLS）。线性回归模型评估UACR与TTE测量的心脏参数之间的关系。结果本研究共纳入104例HT患者。患者平均年龄49.1±9.5岁，男性占44.2%。经过治疗，平均、夜间和白天收缩压（SBP）、脉压和动脉压下降，这些下降与UACR显著相关。此外，微量白蛋白尿随治疗而减少，线性回归分析发现UACR的降低与LVGLS的改善之间存在独立且显著的关联。结论在我们的研究中，微量白蛋白尿与LVGLS之间存在显著关系。我们观察到，减少HT患者微量白蛋白尿和控制血压的治疗与左室功能的改善有关，UACR显示微量白蛋白尿，可能有助于监测左室收缩功能的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.