Color mapping of multitarget protein clusters

IF 4.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Structure Pub Date : 2025-06-05 DOI:10.1016/j.str.2025.05.004

Hirushi Gunasekara, Ying S. Hu

引用次数: 0

Abstract

Visualizing subcellular distributions of proteins and assessing their colocalization patterns are central to understanding the organization and interactions of molecular assemblies. In this issue of Structure, Kiuchi et al.¹ introduce protein cluster coloring to map complex association patterns among eight endogenous proteins at the periphery of the clathrin-coated structure, revealing their multilayered complex associations upon epidermal growth factor stimulation.

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多靶点蛋白簇的颜色映射

可视化蛋白质的亚细胞分布和评估它们的共定位模式是理解分子组装的组织和相互作用的核心。在本期的《结构》杂志中，Kiuchi等人1引入蛋白质簇着色来绘制网格蛋白包被结构外围的8种内源性蛋白质之间的复杂关联模式，揭示了它们在表皮生长因子刺激下的多层复杂关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Structure 生物-生化与分子生物学

CiteScore

8.90

自引率

1.80%

发文量

155

审稿时长

3-8 weeks

期刊介绍： Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.