From genes to geometry: Controlling embryo models by programming genomic activation

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-06-05 DOI:10.1016/j.stem.2025.04.013

Harold M. McNamara, Berna Sozen

引用次数: 0

Abstract

Embryo-like models derived from stem cells have emerged as powerful tools to study early development. In this issue, Lodewijk et al.¹ demonstrate that activating just two enhancers via CRISPR activation (CRISPRa) in mouse embryonic stem cells (ESCs) can drive self-organization into structured embryo-like models, offering a genome-driven approach in stem cell and developmental biology.

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从基因到几何：通过编程基因组激活来控制胚胎模型

来自干细胞的胚胎样模型已经成为研究早期发育的有力工具。在这一期中，Lodewijk等人1证明，通过CRISPR激活（CRISPRa）激活小鼠胚胎干细胞（ESCs）中的两个增强子可以驱动自组织进入结构化的胚胎样模型，为干细胞和发育生物学提供了基因组驱动的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.