KDM4C shields breast cancer from the histone scissor cathepsin L

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-06-05 DOI:10.1038/s41588-025-02200-7

引用次数: 0

Abstract

We uncovered a mechanism by which KDM4C promotes tumorigenesis in basal breast cancer with KDM4C amplification. Using knockdown models, we showed that KDM4C prevents activation of cathepsin L by demethylating its recruiter GRHL2, thereby reducing clipping of histone H3 and oxidative stress and, ultimately, promoting tumor growth.

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KDM4C保护乳腺癌免受组蛋白剪刀组织蛋白酶L的侵害

我们揭示了KDM4C通过KDM4C扩增促进基底乳腺癌肿瘤发生的机制。通过敲低模型，我们发现KDM4C通过去甲基化其招募者GRHL2来阻止组织蛋白酶L的激活，从而减少组蛋白H3的剪切和氧化应激，最终促进肿瘤生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution