Yixiang Lin, Haoling Xu, Jiayi Zheng, Tianxin Lin, Minhui Wang, Tingting Huang, Fabin Lin, Qinyong Ye, Guoen Cai
{"title":"Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study","authors":"Yixiang Lin, Haoling Xu, Jiayi Zheng, Tianxin Lin, Minhui Wang, Tingting Huang, Fabin Lin, Qinyong Ye, Guoen Cai","doi":"10.1038/s41531-025-01000-4","DOIUrl":null,"url":null,"abstract":"<p>The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson’s disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of PD incidence [hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.30–2.33]. Similar results were also observed for functional dyspepsia (HR = 1.71, 95% CI = 1.17–2.52) and other functional intestinal disorders (other FIDs) (HR = 1.67, 95% CI = 1.00–2.78). Mediation analyses revealed that mental health scores mediated 10.00% and 8.32% of the association between FGIDs and functional dyspepsia and PD development. This cohort study discovered that FGIDs increase the risk of developing PD. Similar effects can also be observed in functional dyspepsia and other FIDs and mental health mediates part of the effect of FGIDs and functional dyspepsia on PD.</p>","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"16 1","pages":""},"PeriodicalIF":6.7000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ Parkinson's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41531-025-01000-4","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson’s disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of PD incidence [hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.30–2.33]. Similar results were also observed for functional dyspepsia (HR = 1.71, 95% CI = 1.17–2.52) and other functional intestinal disorders (other FIDs) (HR = 1.67, 95% CI = 1.00–2.78). Mediation analyses revealed that mental health scores mediated 10.00% and 8.32% of the association between FGIDs and functional dyspepsia and PD development. This cohort study discovered that FGIDs increase the risk of developing PD. Similar effects can also be observed in functional dyspepsia and other FIDs and mental health mediates part of the effect of FGIDs and functional dyspepsia on PD.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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