Dietary macronutrient content and energy intake in the mouse: hedonic or homeostatic override?

IF 4.7 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Pub Date : 2025-06-04 DOI:10.1002/oby.24312
Stephen J. Simpson, Alistair M. Senior, Samantha M. Solon-Biet, David G. Le Couteur, David Raubenheimer
{"title":"Dietary macronutrient content and energy intake in the mouse: hedonic or homeostatic override?","authors":"Stephen J. Simpson,&nbsp;Alistair M. Senior,&nbsp;Samantha M. Solon-Biet,&nbsp;David G. Le Couteur,&nbsp;David Raubenheimer","doi":"10.1002/oby.24312","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The objective of this study was to reconcile how two landmark mouse studies came to opposite conclusions regarding the relationship between dietary macronutrient composition and energy intake. Hu et al. concluded that dietary fat drives excess energy intake because its hedonic properties override energy homeostasis. Solon-Biet et al. concluded that energy intake increases with dietary fat owing to the dilution of protein and carbohydrates, with compensatory feeding for these nutrients dominating inhibitory feedback from fat.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Nutritional geometry was used to reanalyze data from Solon-Biet et al. and Hu et al.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Results from the two studies are strongly concordant. Neither was designed to measure hedonics but, in both studies, the positive associations among dietary fat, food, and energy intakes are as predicted by compensatory feeding for dietary protein and carbohydrates without the need to impute hedonic effects of fat.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Whereas conclusions cannot be drawn from either study regarding the role of hedonics, there is evidence for homeostatic feedback operating in both. We suggest that hedonic and homeostatic mechanisms likely interact, with homeostasis being more influential over the longer term. Therefore, “hedonic diversion” may be a more appropriate concept than “hedonic override” when considering energy consumption in mice and, perhaps, humans.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 7","pages":"1322-1333"},"PeriodicalIF":4.7000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24312","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24312","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Objective

The objective of this study was to reconcile how two landmark mouse studies came to opposite conclusions regarding the relationship between dietary macronutrient composition and energy intake. Hu et al. concluded that dietary fat drives excess energy intake because its hedonic properties override energy homeostasis. Solon-Biet et al. concluded that energy intake increases with dietary fat owing to the dilution of protein and carbohydrates, with compensatory feeding for these nutrients dominating inhibitory feedback from fat.

Methods

Nutritional geometry was used to reanalyze data from Solon-Biet et al. and Hu et al.

Results

Results from the two studies are strongly concordant. Neither was designed to measure hedonics but, in both studies, the positive associations among dietary fat, food, and energy intakes are as predicted by compensatory feeding for dietary protein and carbohydrates without the need to impute hedonic effects of fat.

Conclusions

Whereas conclusions cannot be drawn from either study regarding the role of hedonics, there is evidence for homeostatic feedback operating in both. We suggest that hedonic and homeostatic mechanisms likely interact, with homeostasis being more influential over the longer term. Therefore, “hedonic diversion” may be a more appropriate concept than “hedonic override” when considering energy consumption in mice and, perhaps, humans.

Abstract Image

小鼠的饮食宏量营养素含量和能量摄入:快乐的还是自我平衡的?
目的:本研究的目的是调和两项具有里程碑意义的小鼠研究如何在饮食宏量营养素组成与能量摄入之间的关系方面得出相反的结论。Hu等人得出的结论是,膳食脂肪会导致过量的能量摄入,因为它的享乐特性凌驾于能量稳态之上。Solon-Biet等人得出结论,由于蛋白质和碳水化合物的稀释,能量摄入随着膳食脂肪的增加而增加,对这些营养素的补偿性喂养主导了脂肪的抑制反馈。方法:采用营养几何方法对Solon-Biet等和Hu等人的数据进行再分析。结果:两项研究结果高度一致。这两项研究都不是为了测量快乐,但在这两项研究中,膳食脂肪、食物和能量摄入之间的正相关关系都是通过膳食蛋白质和碳水化合物的代偿性喂养来预测的,而不需要推算脂肪的快乐效应。结论:虽然不能从两项研究中得出关于享乐主义作用的结论,但有证据表明,稳态反馈在两者中都起作用。我们认为,享乐和体内平衡机制可能相互作用,体内平衡在长期内更有影响力。因此,在考虑小鼠和人类的能量消耗时,“享乐转移”可能比“享乐覆盖”更合适。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信