Stephen J. Simpson, Alistair M. Senior, Samantha M. Solon-Biet, David G. Le Couteur, David Raubenheimer
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引用次数: 0
Abstract
Objective
The objective of this study was to reconcile how two landmark mouse studies came to opposite conclusions regarding the relationship between dietary macronutrient composition and energy intake. Hu et al. concluded that dietary fat drives excess energy intake because its hedonic properties override energy homeostasis. Solon-Biet et al. concluded that energy intake increases with dietary fat owing to the dilution of protein and carbohydrates, with compensatory feeding for these nutrients dominating inhibitory feedback from fat.
Methods
Nutritional geometry was used to reanalyze data from Solon-Biet et al. and Hu et al.
Results
Results from the two studies are strongly concordant. Neither was designed to measure hedonics but, in both studies, the positive associations among dietary fat, food, and energy intakes are as predicted by compensatory feeding for dietary protein and carbohydrates without the need to impute hedonic effects of fat.
Conclusions
Whereas conclusions cannot be drawn from either study regarding the role of hedonics, there is evidence for homeostatic feedback operating in both. We suggest that hedonic and homeostatic mechanisms likely interact, with homeostasis being more influential over the longer term. Therefore, “hedonic diversion” may be a more appropriate concept than “hedonic override” when considering energy consumption in mice and, perhaps, humans.
期刊介绍:
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.