Clinical Staging and Histopathological Grading of Inguinal Squamous Cell Carcinoma in Dogs: A Case Series Study.

IF 1.7 Q2 VETERINARY SCIENCES
Veterinary medicine (Auckland, N.Z.) Pub Date : 2025-05-28 eCollection Date: 2025-01-01 DOI:10.2147/VMRR.S500469
Ana A Jiménez-Alonso, Carmen G Pérez-Santana, Sara E Cazorla-Rivero, Francisco Rodríguez-Esparragón, Enrique Rodríguez Grau-Bassas
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Abstract

Introduction: Canine cutaneous squamous cell carcinoma (SCC) is a locally invasive tumor with a variable prognosis.

Materials and methods: This study evaluated clinical stage and histopathological grade as prognostic factors. Eleven dogs with inguinal SCC underwent surgery. All dogs presented varying degrees of atopic skin owing to prolonged outdoor ultraviolet (UV) exposure. Tumors are located primarily in the ventro inguinal area, affecting the prepuce and scrotum in males. Clinical staging (TNM system) was performed through abdominal ultrasound and palpation of regional lymph nodes, and histopathologically, Broder grading was applied.

Discussion: The survival time (ST) and disease-free interval (DFI) were analyzed, and the median ST was 738 days for Grade 1 tumors compared with 135 days for Grade 4 tumors. Staging correlated with metastatic risk (1/11 patients).

Conclusion: This study highlights the importance of histological grade as a prognostic factor for canine cutaneous SCC and surgery as a treatment of choice and emphasizes the need for further studies on disease progression and treatment outcomes in veterinary medicine.

犬腹股沟鳞状细胞癌的临床分期和组织病理学分级:一个病例系列研究。
犬皮肤鳞状细胞癌(SCC)是一种局部侵袭性肿瘤,预后不一。材料和方法:本研究评估临床分期和组织病理学分级作为预后因素。11只患有腹股沟SCC的狗接受了手术。由于长时间暴露在室外紫外线下,所有狗都表现出不同程度的特应性皮肤。肿瘤主要位于腹股沟腹区,影响男性包皮和阴囊。通过腹部超声和触诊区域淋巴结进行临床分期(TNM系统),组织病理学上采用Broder分级。讨论:分析生存时间(ST)和无病间期(DFI), 1级肿瘤的中位ST为738天,而4级肿瘤的中位ST为135天。分期与转移风险相关(1/11例)。结论:本研究强调了组织学分级作为犬皮肤鳞状细胞癌的预后因素和手术作为治疗选择的重要性,并强调了在兽医学中对疾病进展和治疗结果进行进一步研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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