Kanimolli Arasu, Winnie Chee Siew Swee, Connie M Weaver
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引用次数: 0
Abstract
Purpose: Normative values of bone mass, bone turnover markers (BTMs) and muscle-bone unit (MBU) among healthy Asian children are needed to enable accurate skeletal assessment. This cross-sectional study characterises the bone mineral density (BMD), bone mineral content (BMC), BTMs and MBU of 243 Malaysian preadolescent children aged between 9 to 11 years.
Methods: Total body BMD (TBBMD), total body BMC (TBBMC), lumbar spine BMD (LSBMD), lumbar spine BMC (LSBMC) and body composition were assessed using dual-energy X-ray absorptiometry. Total and regional MBU was calculated by dividing BMC with lean body mass (LBM). Serum BTMs (CTX1, P1NP, BAP, OC) and serum iPTH were measured.
Results: Based on the Asian reference population, 97.5% of the participants had TBBMD Z-scores above -1 SD, 2.5% were at risk for low TBBMD for age (-1.9 to -1.0 SD) and no one had low TBBMD for age (<-2.0 SD). Participants had lower TBBMD than children of the same age from published data of Asian children despite having higher body weights. There were sex-specific differences in the BTMs and regional MBU of the participants.
Conclusion: This study provides a population-based dataset on bone mass, BTMs, and MBU of healthy preadolescent Malaysian children which enables accurate skeletal assessment in this population.
期刊介绍：
The Annals of Pediatric Endocrinology & Metabolism Journal is the official publication of the Korean Society of Pediatric Endocrinology. Its formal abbreviated title is “Ann Pediatr Endocrinol Metab”. It is a peer-reviewed open access journal of medicine published in English. The journal was launched in 1996 under the title of ‘Journal of Korean Society of Pediatric Endocrinology’ until 2011 (pISSN 1226-2242). Since 2012, the title is now changed to ‘Annals of Pediatric Endocrinology & Metabolism’. The Journal is published four times per year on the last day of March, June, September, and December. It is widely distributed for free to members of the Korean Society of Pediatric Endocrinology, medical schools, libraries, and academic institutions. The journal is indexed/tracked/covered by web sites of PubMed Central, PubMed, Emerging Sources Citation Index (ESCI), Scopus, EBSCO, EMBASE, KoreaMed, KoMCI, KCI, Science Central, DOI/CrossRef, Directory of Open Access Journals(DOAJ), and Google Scholar. The aims of Annals of Pediatric Endocrinology & Metabolism are to contribute to the advancements in the fields of pediatric endocrinology & metabolism through the scientific reviews and interchange of all of pediatric endocrinology and metabolism. It aims to reflect the latest clinical, translational, and basic research trends from worldwide valuable achievements. In addition, genome research, epidemiology, public education and clinical practice guidelines in each country are welcomed for publication. The Journal particularly focuses on research conducted with Asian-Pacific children whose genetic and environmental backgrounds are different from those of the Western. Area of specific interest include the following : Growth, puberty, glucose metabolism including diabetes mellitus, obesity, nutrition, disorders of sexual development, pituitary, thyroid, parathyroid, adrenal cortex, bone or other endocrine and metabolic disorders from infancy through adolescence.
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