Contemporary factors affecting serum 25-hydroxyvitamin D concentrations in Chinese children aged 2-6 years.

IF 3 3区医学 Q2 NUTRITION & DIETETICS

Public Health Nutrition Pub Date : 2025-06-04 DOI:10.1017/S1368980024001320

Qian Chen, Ting Yang, Yongfang Liu, Jie Chen, Qian Cheng, Tingyu Li

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引用次数: 0

Abstract

Objective: We investigated vitamin D (VitD) nutritional status in children aged 2-6 years to provide a basis for prevention and intervention strategies for VitD deficiency (VitDD) in Chinese children.

Design: From November 2018 to September 2019, a total of 2192 healthy children aged 2-6 years were enrolled. The serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography tandem MS.

Setting: Twelve jurisdictions in eight provinces and cities across northern and southern China were selected through stratified cluster sampling.

Participants: 2192 children aged 2-6 years were enrolled.

Results: (1) A serum 25(OH)D concentration of 23·87 (sd 8·24) ng/ml, a VitDS rate of 65·2 %, an insufficiency rate of 29·6 % and a deficiency rate of 5·2 % were noted. (2) Age (OR = 2·22, 95 % CI 1·86, 2·64) and spring (OR = 1·35, 95 % CI 0·91, 2·01) are risk factors for VitDD and VitDI. The male (OR = 0·68, 95 % CI 0·52, 0·90), the temperature (OR = 0·89, 95 % CI 0·86, 0·93), summer (OR = 0·25, 95 % CI 0·09, 0·68), autumn (OR = 0·26, 95 % CI 0·09, 0·74) the intake of VitD supplements (OR = 0·08, 95 % CI 0·03, 0·28), the intake frequency of dairy products (OR = 0·86, 95 % CI 0·78, 0·96) and egg products (OR = 0·83, 95 % CI 0·74, 0·93) are protective factors for VitDD and VitDI.

Conclusion: VitDD in children aged 2-6 years is still prevalent in China, but the influencing factors of VitD nutrition have changed. Latitude is not the main factor in the 25(OH)D concentrations of children aged 2-6 years; temperature, intake of eggs and dairy products and sampling season have more obvious impacts.

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影响中国2-6岁儿童血清25-羟基维生素D浓度的当代因素

目的：了解2 ~ 6岁儿童维生素D （VitD）营养状况，为我国儿童维生素D缺乏症（VitDD）的预防和干预策略提供依据。设计：2018年11月至2019年9月，共入组2192名2-6岁健康儿童。采用液相色谱串联ms法测定血清25(OH)D （25(OH)D）浓度。背景：采用分层整群抽样的方法，选取了中国南北8个省市的12个辖区。参与者：2192名2-6岁儿童。结果：(1)血清25(OH)D浓度为23.87 (sd 8.24) ng/ml， VitDS率为65.2%，不足率为29.6%，不足率为5.2%。(2)年龄（OR = 2.22, 95% CI 1.86, 2.64）和春季（OR = 1.35, 95% CI 0.91, 2.01）是VitDD和VitDI的危险因素。男性(或= 0·68,52岁的95%可信区间0·0·90)、温度(或= 0·89,95%可信区间0·86,0·93),夏季(25 = 0·95%可信区间0·09年0·68),秋天(或= 0·26日95%可信区间0·09年,0·74)的摄入VitD补充剂(或= 0·08年,95%可信区间0·03,0·28),奶制品的摄入频率(或= 0·86,95%可信区间0·78,0·96)和蛋制品(或= 0·83,95%可信区间0·74,0·93)是VitDD和VitDI保护性因素。结论：中国2 ~ 6岁儿童维生素d仍普遍存在，但维生素d营养的影响因素发生了变化。纬度不是影响2 ~ 6岁儿童25(OH)D浓度的主要因素；温度、鸡蛋和奶制品的摄入量以及采样季节对其影响更为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.10

自引率

6.20%

发文量

521

审稿时长

3 months

期刊介绍： Public Health Nutrition provides an international peer-reviewed forum for the publication and dissemination of research and scholarship aimed at understanding the causes of, and approaches and solutions to nutrition-related public health achievements, situations and problems around the world. The journal publishes original and commissioned articles, commentaries and discussion papers for debate. The journal is of interest to epidemiologists and health promotion specialists interested in the role of nutrition in disease prevention; academics and those involved in fieldwork and the application of research to identify practical solutions to important public health problems.