Early menopause, hysterectomy, and biological aging: Health and Retirement Study.

IF 3 3区 医学 Q1 OBSTETRICS & GYNECOLOGY
Jung Ki Kim, Eileen M Crimmins
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引用次数: 0

Abstract

Objective: This study examines the association between the timing of menopause and hysterectomy and biological aging, focusing on epigenetic and physiological aging markers.

Methods: Data were analyzed from women aged 56 and over in the nationally representative Health and Retirement Study (HRS). Regressions of biological aging measured by accelerated epigenetic aging and biological age based on physiological dysregulation on menopause/hysterectomy history were conducted to examine associations of normal-aged and early menopause with and without hysterectomy with biological aging.

Results: Hysterectomy, whether following normal-aged or early menopause, or in younger ages, was significantly associated with markers of accelerated biological aging. Women with early menopause or hysterectomy showed accelerated epigenetic aging. Early menopause was associated with accelerated physiological dysregulation only when combined with hysterectomy, suggesting that surgical menopause may be related to accelerated systemic aging processes. Epigenetic clocks were associated with early cellular and molecular aging changes linked to natural early menopause, while physiological dysregulation was associated with the cumulative systemic impacts related to hysterectomy.

Conclusions: This study highlights associations between reproductive history and biological aging. These findings underscore the importance of considering both natural and surgical factors in menopause in evaluating aging-related health risks and suggest avenues for targeted interventions to mitigate health risks in women with these reproductive histories.

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Abstract Image

早期绝经、子宫切除和生物老化:健康与退休研究。
目的:本研究探讨绝经时间和子宫切除术与生物衰老之间的关系,重点研究表观遗传和生理衰老标志物。方法:对具有全国代表性的健康与退休研究(HRS)中56岁及以上女性的数据进行分析。通过加速表观遗传衰老和基于绝经/子宫切除术史生理失调的生物年龄测量生物衰老的回归,研究了正常年龄和早期绝经与子宫切除术和不切除子宫与生物衰老的关系。结果:子宫切除术,无论是在正常年龄或早期绝经后,还是在更年轻的年龄,都与加速生物衰老的标志物显著相关。早期绝经或子宫切除的妇女表现出加速的表观遗传衰老。早期绝经与加速的生理失调只有在联合子宫切除术时才相关,这表明手术绝经可能与加速的全身衰老过程有关。表观遗传时钟与自然提前绝经相关的早期细胞和分子衰老变化有关,而生理失调与子宫切除术相关的累积系统性影响有关。结论:本研究强调了生殖史与生物衰老之间的关系。这些发现强调了在评估与年龄相关的健康风险时考虑更年期的自然因素和手术因素的重要性,并为有针对性的干预措施提供了途径,以减轻有这些生殖史的妇女的健康风险。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
330
审稿时长
3-8 weeks
期刊介绍: ​Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.
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