The Association Between High-Sensitivity C-Reactive Protein and the Progression of Arteriosclerosis: The Kailuan Study.

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.2147/JIR.S524495

Weizhe Li, Pei Liang, Xueliang Ma, Yanling Gao, Xiaoxin Bai, Shasha An, Xin Wang, Shuohua Chen, Shouling Wu

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引用次数: 0

Abstract

Objective: To explore the association between high-sensitivity C-reactive protein (hs-CRP) and the progression of arteriosclerosis.

Methods: Using a prospective cohort study design, 11,577 participants from the Kailuan Study cohort who underwent at least two brachial-ankle pulse wave velocity (baPWV) examinations and met the inclusion criteria were included as the study subjects. Based on baseline hs-CRP levels, they were divided into three groups: hs-CRP <1 mg/L group, 1 mg/L≤hs-CRP≤3 mg/L group, and hs-CRP >3 mg/L group. Poisson regression analysis was employed for longitudinal comparison to assess the impact of different hs-CRP levels on baPWV≥1,400 cm/s.

Results: (1) After a mean follow-up of 5.12 ± 2.84 years, the detection rates of baPWV≥1,400 cm/s at the end of follow-up were 28.54%, 33.36%, and 36.25% in the hs-CRP<1 mg/L (n=5,998), 1 mg/L≤ hs-CRP≤3 mg/L (n=4,101), and hs-CRP>3 mg/L (n=1,578) groups, respectively (P<0.001). (2) Multivariable-adjusted Poisson regression analysis for baPWV≥1,400 cm/s showed that, after adjusting for confounding factors, compared to the hs-CRP<1 mg/L group, the 1 mg/L≤hs-CRP≤3 mg/L group had a 2.4% higher risk of arterial stiffness (RR: 1.024; 95% CI: 1.002 to 1.047; P<0.05) and hs-CRP>3 mg/L group had a 6.3% higher risk (RR: 1.063; 95% CI: 1.031 to 1.095; P<0.001). Sensitivity analysis validated the robustness of the results.

Conclusion: Elevated hs-CRP is an independent risk factor for arteriosclerosis progression.

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高敏c反应蛋白与动脉硬化进展的关系：开滦研究。

目的：探讨高敏c反应蛋白（hs-CRP）与动脉硬化进展的关系。方法：采用前瞻性队列研究设计，从开滦研究队列中选取11,577名至少接受两次肱-踝脉波速度（baPWV）检查并符合纳入标准的参与者作为研究对象。根据hs-CRP基线水平分为3组：hs-CRP 3mg /L组。采用泊松回归分析进行纵向比较，评估不同hs-CRP水平对baPWV≥1400 cm/s的影响。结果：(1)平均随访5.12±2.84年，hs-CRP3 mg/L组（n= 1578）随访结束时baPWV≥1400 cm/s检出率分别为28.54%、33.36%和36.25%，其中PP3 mg/L组风险高6.3% (RR: 1.063；95% CI: 1.031 ~ 1.095；结论：hs-CRP升高是动脉硬化进展的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.