Anorexia Nervosa-Facts, Frustrations, and the Future.

IF 17.1 1区医学 Q1 PSYCHIATRY

JAMA Psychiatry Pub Date : 2025-08-01 DOI:10.1001/jamapsychiatry.2025.0812

Andrea Phillipou, Ulrike Schmidt, Erica Neill, Stephanie Miles, Patrick McGorry, Kamryn T Eddy

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Abstract

Importance: Anorexia nervosa is a prevalent psychiatric illness associated with exceptionally poor outcomes, including high rates of morbidity and premature mortality. Current evidence-based treatments for anorexia nervosa were developed several decades ago and have limited efficacy. The anorexia nervosa field-and the eating disorders field more broadly-has yet to make significant scientific breakthroughs that lead to acceptable outcomes for people with anorexia nervosa.

Findings: This Special Communication highlights how the concurrent psychological and physical symptoms of anorexia nervosa contribute to 2 major problems that have held the anorexia nervosa research field back and hindered research innovations: (1) overspecialization and siloing of the field and (2) an overly narrow focus on weight restoration in treatment.

Conclusions and relevance: Specific recommendations are made to help progress the field, including taking a multidisciplinary and collaborative approach to research with colleagues from related disciplines, as well as taking a more holistic approach to understanding and treating anorexia nervosa.

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神经性厌食症——事实、挫折和未来。

重要性：神经性厌食症是一种普遍的精神疾病，其预后异常差，包括高发病率和过早死亡率。目前针对神经性厌食症的循证治疗是几十年前发展起来的，疗效有限。神经性厌食症领域——以及更广泛的饮食失调领域——尚未取得重大的科学突破，为神经性厌食症患者带来可接受的结果。本专题交流强调神经性厌食症并发的心理和生理症状是如何导致神经性厌食症研究领域停滞不前并阻碍研究创新的两个主要问题：(1)该领域的过度专业化和孤立化；(2)治疗中对体重恢复的关注过于狭隘。结论和相关性：提出了具体的建议，以帮助该领域的发展，包括采取多学科合作的方式与相关学科的同事进行研究，以及采取更全面的方法来理解和治疗神经性厌食症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JAMA Psychiatry PSYCHIATRY-

CiteScore

30.60

自引率

1.90%

发文量

233

期刊介绍： JAMA Psychiatry is a global, peer-reviewed journal catering to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and related fields. The Archives of Neurology & Psychiatry originated in 1919, splitting into two journals in 1959: Archives of Neurology and Archives of General Psychiatry. In 2013, these evolved into JAMA Neurology and JAMA Psychiatry, respectively. JAMA Psychiatry is affiliated with the JAMA Network, a group of peer-reviewed medical and specialty publications.