pH-triggered CS@ZnO2 nanocomposites: Self-activated ROS generation for efficient bacterial eradication.

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1608188
Yu Zhang, Jun Liu, Sha Li, Jinhua Zhou, Jiushan Liu, Yan Huang
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Abstract

Functional nanomaterials based on reactive oxygen species (ROS) have attracted considerable attention in the treatment of bacterial infections, owing to their high sterilization efficiency and low tendency to induce drug resistance. Natural polymers, known for their excellent biocompatibility, have been widely used in the development of antibacterial dressings. In this study, chitosan-zinc peroxide composite dressing (CS@ZnO2) was synthesized using zinc acetate and chitosan as primary raw materials, and comprehensive characterizations were performed. Under the slightly acidic conditions of bacterial infections, CS@ZnO2 could self-decompose to release H2O2 and produce large amount of ROS, which would cause damage to bacteria. The in vitro antibacterial properties of CS@ZnO2 were investigated using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as representative pathogens. The results demonstrated that CS@ZnO2 exhibited potent antibacterial efficacy against both S. aureus and E. coli. This research provides an important theoretical foundation and technical support for the development of novel antibacterial materials, and has the potential to improve the efficacy of treatments for bacterial infections in the future.

ph触发CS@ZnO2纳米复合材料:自激活ROS生成有效的细菌根除。
基于活性氧(ROS)的功能纳米材料因其灭菌效率高、耐药倾向低而在细菌感染的治疗中受到广泛关注。天然聚合物以其优异的生物相容性被广泛应用于抗菌敷料的开发。本研究以乙酸锌和壳聚糖为主要原料,合成了壳聚糖-过氧化锌复合敷料(CS@ZnO2),并对其进行了综合表征。在细菌感染的微酸性条件下,CS@ZnO2可自分解释放H2O2,产生大量ROS,对细菌造成损伤。以大肠杆菌(E. coli)和金黄色葡萄球菌(S. aureus)为代表病原菌,研究CS@ZnO2的体外抗菌性能。结果表明CS@ZnO2对金黄色葡萄球菌和大肠杆菌均有较强的抗菌作用。本研究为新型抗菌材料的开发提供了重要的理论基础和技术支持,具有未来提高细菌感染治疗效果的潜力。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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